Sex as a Biological Variable in Nutrition Research: From Human Studies to Animal Models

被引：36

作者：

Chen, Yilin ^{[1
]}

Kim, Minhoo ^{[1
]}

Paye, Sanjana ^{[2
]}

Benayoun, Berenice A. ^{[1
,2
,3
,4
,5
]}

机构：

[1] Univ Southern Calif, Leonard Davis Sch Gerontol, Los Angeles, CA 90007 USA

[2] Univ Southern Calif, Dornsife Coll Letters Arts & Sci, Dept Mol & Computat Biol, Los Angeles, CA 90007 USA

[3] Univ Southern Calif, Keck Sch Med, Dept Biochem & Mol Med, Los Angeles, CA 90007 USA

[4] USC Norris Comprehens Canc Ctr, Epigenet & Gene Regulat Program, Los Angeles, CA 90033 USA

[5] Univ Southern Calif, USC Stem Cell Initiat, Los Angeles, CA 90007 USA

来源：

ANNUAL REVIEW OF NUTRITION | 2022年 / 42卷

关键词：

HORMONE-REPLACEMENT THERAPY; GENDER-DIFFERENCES; GUT MICROBIOME; CALORIC RESTRICTION; GONADAL-HORMONES; FASTING GLUCOSE; ENERGY-BALANCE; FAT; BRAIN; MICE;

D O I：

10.1146/annurev-nutr-062220-105852

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

Biological sex is a fundamental source of phenotypic variability across species. Males and females have different nutritional needs and exhibit differences in nutrient digestion and utilization, leading to different health outcomes throughout life. With personalized nutrition gaining popularity in scientific research and clinical practice, it is important to understand the fundamentals of sex differences in nutrition research. Here, we review key studies that investigate sex dimorphism in nutrition research: sex differences in nutrient intake and metabolism, sex-dimorphic response in nutrient-restricted conditions, and sex differences in diet and gut microbiome interactions. Within each area above, factors from sex chromosomes, sex hormones, and sex-specific loci are highlighted.

引用

页码：227 / 250

页数：24

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