Animal models of inhibitors

被引：13

作者：

Reipert, B. ^{[2
]}

Arruda, V. ^{[3
]}

Lillicrap, D. ^{[1
]}

机构：

[1] Queens Univ, Dept Pathol & Mol Med, Richardson Lab, Kingston, ON K7L 3N6, Canada

[2] Baxter Biosci, Vienna, Austria

[3] Univ Penn, Dept Pediat, Childrens Hosp Philadelphia, Philadelphia, PA 19104 USA

来源：

HAEMOPHILIA | 2010年 / 16卷

关键词：

Hemophilia; inhibitors; immunity; factor VII; animal models; FACTOR-VIII INHIBITORS; SEVERE HEMOPHILIA-A; LONG-TERM CORRECTION; GENE-THERAPY; CLASS-II; IMMUNE TOLERANCE; DENDRITIC CELLS; FACTOR-IX; B-CELLS; IMMUNOLOGICAL-TOLERANCE;

D O I：

10.1111/j.1365-2516.2010.02293.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Antibody responses to clotting factor concentrates remain a major treatment limitation. In conjucation with ongoing clinical studies, the pathogenesis and potential treatment of clotting factor immune responses is being evaluated in a variety of animal models.

引用

页码：47 / 53

页数：7

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