Dibenzocyclooctane lignans from the stems of Kadsura induta and their antiviral effect on hepatitis B virus

被引：27

作者：

Ma, Wenhui

Ma, Xiaolin

Huang, Hai

Zhou, Pei

Chen, Daofeng ^{[1
]}

机构：

[1] Fudan Univ, Sch Pharm, Dept Pharmacognosy, Shanghai 200032, Peoples R China

[2] Fudan Univ, Sch Pharm, Dept Biosynthet Med Chem, Shanghai 200032, Peoples R China

来源：

CHEMISTRY & BIODIVERSITY | 2007年 / 4卷 / 05期

关键词：

D O I：

10.1002/cbdv.200790087

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Two new dibenzocyclooctane lignans, kadsurindutins A (1) and B (2), were isolated from the stems of Kadsura induta, together with the known, structurally related lignans schisantherin L (3), schisantherin P (4), kadsulignan L (5), and neokadsuranin (6). Their structures and configurations were elucidated by spectroscopic methods (UV, ORD, CD, IR, 1D- and 2D-NMR) in combination with mass-spectrometric (HR-MS) techniques. Compounds 1, 5, and 6 showed in vitro antiviral effects on hepatitis B virus.

引用

页码：966 / 972

页数：7

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