Standardized gait speed ratio in elderly patients with heart failure

被引：19

作者：

Ozawa, Tetsuya ^{[1
]}

Yamashita, Masashi ^{[2
]}

Seino, Satoshi ^{[3
]}

Kamiya, Kentaro ^{[4
]}

Kagiyama, Nobuyuki ^{[5
,6
,7
]}

Konishi, Masaaki ^{[8
]}

Saito, Hiroshi ^{[9
,10
]}

Saito, Kazuya ^{[11
]}

Ogasahara, Yuki ^{[12
]}

Maekawa, Emi ^{[13
]}

Kitai, Takeshi ^{[14
]}

Iwata, Kentaro ^{[15
]}

Jujo, Kentaro ^{[16
]}

Wada, Hiroshi ^{[17
]}

Kasai, Takatoshi ^{[10
,18
]}

Momomura, Shin-ichi ^{[19
]}

Hamazaki, Nobuaki ^{[20
]}

Nozaki, Kohei ^{[20
]}

Kim, Hunkyung ^{[3
]}

Obuchi, Shuichi ^{[3
]}

Kawai, Hisashi ^{[3
]}

Kitamura, Akihiko ^{[3
]}

Shinkai, Shoji ^{[3
]}

Matsue, Yuya ^{[10
,18
]}

机构：

[1] Odawara Municipal Hosp, Dept Rehabil, Odawara, Kanagawa, Japan

[2] Kitasato Univ, Dept Rehabil Sci, Grad Sch Med Sci, Sagamihara, Kanagawa, Japan

[3] Tokyo Metropolitan Inst Gerontol, Tokyo, Japan

[4] Kitasato Univ, Sch Allied Hlth Sci, Dept Rehabil, Sagamihara, Kanagawa, Japan

[5] Sakakibara Heart Inst Okayama, Dept Cardiol, Okayama, Japan

[6] Juntendo Univ, Dept Digital Hlth & Telemed R&D, Tokyo, Japan

[7] Juntendo Univ, Fac Med, Dept Cardiovasc Biol & Med, Tokyo, Japan

[8] Yokohama City Univ, Div Cardiol, Med Ctr, Yokohama, Kanagawa, Japan

[9] Kameda Med Ctr, Dept Rehabil, Kamogawa, Japan

[10] Juntendo Univ, Dept Cardiovasc Biol & Med, Grad Sch Med, Tokyo, Japan

[11] Sakakibara Heart Inst Okayama, Dept Rehabil, Okayama, Japan

[12] Sakakibara Heart Inst Okayama, Dept Nursing, Okayama, Japan

[13] Kitasato Univ, Dept Cardiovasc Med, Sch Med, Sagamihara, Kanagawa, Japan

[14] Kobe City Med Ctr, Dept Cardiovasc Med, Gen Hosp, Kobe, Hyogo, Japan

[15] Kobe City Med Ctr, Dept Rehabil, Gen Hosp, Kobe, Hyogo, Japan

[16] Nishiarai Heart Ctr Hosp, Dept Cardiol, Tokyo, Japan

[17] Jichi Med Univ, Saitama Med Ctr, Dept Cardiovasc Med, Saitama, Japan

[18] Juntendo Univ, Grad Sch Med, Cardiovasc Resp Sleep Med, Bunkyo Ku, 2-1-1 Hongo, Tokyo 1138421, Japan

[19] Saitama Citizens Med Ctr, Saitama, Japan

[20] Kitasato Univ Hosp, Dept Rehabil, Sagamihara, Kanagawa, Japan

来源：

ESC HEART FAILURE | 2021年 / 8卷 / 05期

基金：

日本科学技术振兴机构; 日本学术振兴会;

关键词：

Frailty; Gait speed; Geriatrics; Mortality; HOSPITALIZATIONS; DIAGNOSIS; SURVIVAL; MOBILITY; OUTCOMES;

D O I：

10.1002/ehf2.13392

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Aims Although aging is strongly associated with both heart failure and a decline in gait speed, a definition of slowness incorporating an age-related decline has yet to be developed. We aimed to define an event-driven cut-off for the relative decline in gait speed against age-adjusted reference values derived from the general population and evaluate its prognostic implications. Methods and results Standardized gait speed (SGS) was defined as the median gait speed stratified by age, sex, and height in 3777 elderly (age >= 65 years) individuals without a history of cardiovascular diseases (Tokyo Metropolitan Institute of Gerontology-Longitudinal Interdisciplinary Study on Aging: general population cohort). The mortality event-driven optimal cut-off of the SGS ratio (actual gait speed divided by the respective SGS) was defined using FRAGILE-HF cohort data and externally validated using Kitasato cohort data, comprising 1301 and 1247 hospitalized elderly patients with heart failure, respectively. Using FRAGILE-HF data, the optimal SGS ratio cut-off was determined as 0.527. In the Kitasato cohort, SGS ratio < 0.527 was associated with a higher 1 year [hazard ratio (HR): 1.70, 95% confidence interval (CI): 1.07-2.72, P = 0.024] and long-term (HR: 1.46, 95% CI: 1.05-2.02, P = 0.024) mortality rate, independent of pre-existing covariates. Conclusions Gait speed was significantly declined in patients with heart failure, even after taking age and sex-related decline into account. A SGS ratio of 0.527 is a validated cut-off for slowness independently associated with mortality in patients with heart failure age >= 65.

引用

页码：3557 / 3565

页数：9

共 23 条

[1] The Global Health and Economic Burden of Hospitalizations for Heart Failure Lessons Learned From Hospitalized Heart Failure Registries [J].

Ambrosy, Andrew P. ;

Fonarow, Gregg C. ;

Butler, Javed ;

Chioncel, Ovidiu ;

Greene, Stephen J. ;

Vaduganathan, Muthiah ;

Nodari, Savina ;

Lam, Carolyn S. P. ;

Sato, Naoki ;

Shah, Ami N. ;

Gheorghiade, Mihai .

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2014, 63 (12) :1123-1133

[2] Risk Factors for Hospital Admission Among Older Persons With Newly Diagnosed Heart Failure Findings From the Cardiovascular Health Study [J].

Chaudhry, Sarwat I. ;

McAvay, Gail ;

Chen, Shu ;

Whitson, Heather ;

Newman, Anne B. ;

Krumholz, Harlan M. ;

Gill, Thomas M. .

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2013, 61 (06) :635-642

[3] Sarcopenia in Asia: Consensus Report of the Asian Working Group for Sarcopenia [J].

Chen, Liang-Kung ;

Liu, Li-Kuo ;

Woo, Jean ;

Assantachai, Prasert ;

Auyeung, Tung-Wai ;

Bahyah, Kamaruzzaman Shahrul ;

Chou, Ming-Yueh ;

Chen, Liang-Yu ;

Hsu, Pi-Shan ;

Krairit, Orapitchaya ;

Lee, Jenny S. W. ;

Lee, Wei-Ju ;

Lee, Yunhwan ;

Liang, Chih-Kuang ;

Limpawattana, Panita ;

Lin, Chu-Sheng ;

Peng, Li-Ning ;

Satake, Shosuke ;

Suzuki, Takao ;

Won, Chang Won ;

Wu, Chih-Hsing ;

Wu, Si-Nan ;

Zhang, Teimei ;

Zeng, Ping ;

Akishita, Masahiro ;

Arai, Hidenori .

JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION, 2014, 15 (02) :95-101

[4] Sarcopenia: revised European consensus on definition and diagnosis [J].

Cruz-Jentoft, Alfonso J. ;

Bahat, Gulistan ;

Bauer, Juergen ;

Boirie, Yves ;

Bruyere, Olivier ;

Cederholm, Tommy ;

Cooper, Cyrus ;

Landi, Francesco ;

Rolland, Yves ;

Sayer, Avan Aihie ;

Schneider, Stephane M. ;

Sieber, Cornel C. ;

Topinkova, Eva ;

Vandewoude, Maurits ;

Visser, Marjolein ;

Zamboni, Mauro .

AGE AND AGEING, 2019, 48 (01) :16-31

[5] Hospitalizations After Heart Failure Diagnosis A Community Perspective [J].

Dunlay, Shannon M. ;

Redfield, Margaret M. ;

Weston, Susan A. ;

Therneau, Terry M. ;

Long, Kirsten Hall ;

Shah, Nilay D. ;

Roger, Veronique L. .

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2009, 54 (18) :1695-1702

[6] Sarcopenia: An Undiagnosed Condition in Older Adults. Current Consensus Definition: Prevalence, Etiology, and Consequences. International Working Group on Sarcopenia [J].

Fielding, Roger A. ;

Vellas, Bruno ;

Evans, William J. ;

Bhasin, Shalender ;

Morley, John E. ;

Newman, Anne B. ;

van Kan, Gabor Abelian ;

Andrieu, Sandrine ;

Bauer, Juergen ;

Breuille, Denis ;

Cederholm, Tommy ;

Chandler, Julie ;

De Meynard, Capucine ;

Donini, Lorenzo ;

Harris, Tamara ;

Kannt, Aimo ;

Guibert, Florence Keime ;

Onder, Graziano ;

Papanicolaou, Dimitris ;

Rolland, Yves ;

Rooks, Daniel ;

Sieber, Cornet ;

Souhami, Elisabeth ;

Verlaan, Sjors ;

Zamboni, Mauro .

JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION, 2011, 12 (04) :249-256

[7]

Go AS, 2013, CIRCULATION, V127, P143, DOI [10.1161/CIR.0b013e318282ab8f, 10.1161/CIR.0000000000000366]

[8] Relationship between test methodology and mean velocity in timed walk tests: A review [J].

Graham, James E. ;

Ostir, Glenn V. ;

Kuo, Yong-Fang ;

Fisher, Steven R. ;

Ottenbacher, Kenneth J. .

ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION, 2008, 89 (05) :865-872

[9] Gait speed has comparable prognostic capability to six-minute walk distance in older patients with cardiovascular disease [J].

Kamiya, Kentaro ;

Hamazaki, Nobuaki ;

Matsue, Yuya ;

Mezzani, Alessandro ;

Corra, Ugo ;

Matsuzawa, Ryota ;

Nozaki, Kohei ;

Tanaka, Shinya ;

Maekawa, Emi ;

Noda, Chiharu ;

Yamaoka-Tojo, Minako ;

Matsunaga, Atsuhiko ;

Masuda, Takashi ;

Ako, Junya .

EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY, 2018, 25 (02) :212-219

[10] Exploring effective items of physical function in slow walking speed and self-reported mobility limitation in community-dwelling older adults [J].

Kim, Mi-Ji ;

Yabushita, Noriko ;

Tanaka, Kiyoji .

GERIATRICS & GERONTOLOGY INTERNATIONAL, 2012, 12 (01) :50-58

← 1 2 3 →