Mouse Homologue of the Schizophrenia Susceptibility Gene ZNF804A as a Target of Hoxc8

被引：16

作者：

Chung, Hyun Joo ^{[1
]}

Lee, Ji-Yeon ^{[1
]}

Deocaris, Custer C. ^{[1
]}

Min, Hyehyun ^{[1
]}

Kim, Sang Hoon ^{[1
]}

Kim, Myoung Hee ^{[1
]}

机构：

[1] Yonsei Univ, Coll Med, Dept Anat, Embryol Lab,Brain Korea Project Med Sci 21, Seoul 120752, South Korea

来源：

JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY | 2010年

关键词：

TGF-BETA; IDENTIFICATION; EXPRESSION; TRANSCRIPTION; BINDING; CELLS;

D O I：

10.1155/2010/231708

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Using a ChIP-cloning technique, we identified a Zinc finger protein 804a (Zfp804a) as one of the putative Hoxc8 downstream target genes. We confirmed binding of Hoxc8 to an intronic region of Zfp804a by ChIP-PCR in F9 cells as well as in mouse embryos. Hoxc8 upregulated Zfp804a mRNA levels and augmented minimal promoter activity in vitro. In E11.5 mouse embryos, Zfp804a and Hoxc8 were coexpressed. Recent genome-wide studies identified Zfp804a (or ZNF804A in humans) as a plausible marker for schizophrenia, leading us to hypothesize that this embryogenic regulatory control might also exert influence in development of complex traits such as psychosis.

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