Design and Synthesis of Oleanolic Acid Rings A and C Lactone Derivatives

被引：2

作者：

Yu, Fei ^{[1
]}

Zheng, Yongxiang ^{[2
]}

Peng, Yiyun ^{[2
]}

Zhou, Demin ^{[2
]}

Xiao, Sulong ^{[2
]}

机构：

[1] Kunming Univ Sci & Technol, Fac Med, Kunming 650500, Peoples R China

[2] Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China

来源：

CHINESE JOURNAL OF ORGANIC CHEMISTRY | 2016年 / 36卷 / 03期

关键词：

oleanolic acid; Baeyer-Villiger reaction; lactone; OLEANANE-TYPE TRITERPENES; BIOLOGICAL EVALUATION;

D O I：

10.6023/cjoc204509001

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Oleanolic acid (OA), a naturally occurring triterpene, was found to have a variety of biological and pharmacological properties. To expand its structural diversity, a series of oleanolic acid derivatives, including ring A and/or ring C expansion, were performed via Baeyer-Villiger reaction using m-CPBA and urea-hydrogen peroxide. The structures of all products were characterized by H-1 NMR, C-13 NMR and HRMS.

引用

页码：512 / 519

页数：8

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