Stereoselective synthesis of (2R,5R)- and (2S,5R)-5-hydroxylysine

被引：0

作者：

van den Nieuwendijk, AMCH ^{[1
]}

Kriek, NMAJ ^{[1
]}

Brussee, J ^{[1
]}

van Boom, JH ^{[1
]}

van der Gen, A ^{[1
]}

机构：

[1] Leiden Univ, Leiden Inst Chem, Gorlaeus Labs, NL-2300 RA Leiden, Netherlands

来源：

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2000年 / 2000卷 / 22期

关键词：

asymmetric synthesis; natural products; cyanohydrins; template synthesis; amino acids;

D O I：

暂无

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A stereoselective synthesis of (2S,5R)-5-hydroxylysine (1) and (2R,5R)-5-hydroxylysine (17), based on a concept involving Williams glycine template methodology and (R)-hydroxynitrile lyase for the introduction of chirality at the alpha -position and the side-chain, respectively, is described. This strategy offers an expeditious route towards orthogonally protected 5-hydroxylysines.

引用

页码：3683 / 3691

页数：9

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