Solvent-free synthesis of polyhydroquinoline and 1,8-dioxodecahydroacridine derivatives through the Hantzsch reaction catalyzed by a natural organic acid: A green method

被引：37

作者：

Sehout, Imene ^{[1
]}

Boulcina, Raouf ^{[1
]}

Boumoud, Boudjemaa ^{[1
]}

Boumoud, Taous ^{[1
]}

Debache, Abdelmadjid ^{[1
]}

机构：

[1] Univ Freres Mentouri Constantine 1, Fac Sci Exactes, Lab Synth Mol Interets Biol, Constantine, Algeria

来源：

SYNTHETIC COMMUNICATIONS | 2017年 / 47卷 / 12期

关键词：

1,8-Dioxodecahydroacridine; ascorbic acid; Hantzsch reaction; polyhydroquinoline; solvent-free conditions; ONE-POT SYNTHESIS; IONIC LIQUID; EFFICIENT; TRIPHENYLPHOSPHINE; DIHYDROPYRIDINES; TEMPERATURE; ACRIDINE;

D O I：

10.1080/00397911.2017.1316406

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Solvent-free and high yielding one-pot synthesis of 1,8-dioxodecahydroacridine and polyhydroquinoline derivatives have been described through Hantzsch condensation of various aldehydes, ammonium acetate with cyclic 1,3-dicarbonyl compounds and ethyl acetoacetate in a very simple, efficient, and environmentally benign method using ascorbic acid as a nontoxic organocatalyst.

引用

页码：1185 / 1191

页数：7

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