Calcium phosphate/microgel composites for 3D powderbed printing of ceramic materials

被引：21

作者：

Birkholz, Mandy-Nicole ^{[2
]}

Agrawal, Garima ^{[1
]}

Bergmann, Christian ^{[2
]}

Schroeder, Ricarda ^{[1
]}

Lechner, Sebastian J. ^{[1
]}

Pich, Andrij ^{[1
]}

Fischer, Horst ^{[2
]}

机构：

[1] Rhein Westfal TH Aachen, Funct & Interact Polymers, DWI, Leibniz Inst Interact Mat eV, Forckenbeckstr 50, D-52056 Aachen, Germany

[2] RWTH Aachen Univ Hosp, Dept Dent Mat & Biomat Res, Aachen, Germany

来源：

BIOMEDICAL ENGINEERING-BIOMEDIZINISCHE TECHNIK | 2016年 / 61卷 / 03期

关键词：

3D printing; beta-tricalcium phosphate; bone substitute; composite; microgel; BETA-TRICALCIUM PHOSPHATE; MECHANICAL-PROPERTIES; AQUEOUS MICROGELS; BONE REGENERATION; TEMPERATURE; SCAFFOLDS; POLYMER; PH; NANOPARTICLES; INFILTRATION;

D O I：

10.1515/bmt-2014-0141

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Composites of microgels and calcium phosphates are promising as drug delivery systems and basic components for bone substitute implants. In this study, we synthesized novel composite materials consisting of pure beta-tricalcium phosphate and stimuli-responsive poly(N-vinylcaprolactam-co-acetoacetoxyethyl methacrylate-co-vinylimidazole) microgels. The chemical composition, thermal properties and morphology for obtained composites were extensively characterized by Fourier transform infrared, X-ray photoelectron spectroscopy, IGAsorp moisture sorption analyzer, thermogravimetric analysis, granulometric analysis, ESEM, energy dispersive X-ray spectroscopy and TEM. Mechanical properties of the composites were evaluated by ball-on-three-balls test to determine the biaxial strength. Furthermore, initial 3D powderbed-based printing tests were conducted with spray-dried composites and diluted 2-propanol as a binder to evaluate a new binding concept for beta-tricalcium phosphate-based granulates. The printed ceramic bodies were characterized before and after a sintering step by ESEM. The hypothesis that the microgels act as polymer adhesive agents by efficient chemical interactions with the beta-tricalcium phosphate particles was confirmed. The obtained composites can be used for the development of new scaffolds.

引用

页码：267 / 279

页数：13

共 52 条

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