Anastatins A and B, new skeletal flavonoids with hepatoprotective activities from the desert plant Anastatica hierochuntica

被引：70
|
作者：
Yoshikawa, M [1 ]
Xu, FM [1 ]
Morikawa, T [1 ]
Ninomiya, K [1 ]
Matsuda, H [1 ]
机构：
[1] Kyoto Pharmaceut Univ, Kyoto 6078412, Japan
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2003年 / 13卷 / 06期
关键词：
D O I：
10.1016/S0960-894X(03)00088-X
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
New skeletal flavonoids, anastatins A and B, were isolated from the methanolic extract of an Egyptian medicinal herb, the whole plants of Anastatica hierochuntica. Their flavanone structures having a benzofuran moiety were determined on the basis of chemical and physicochemical evidence. Anastatins A and B were found to show hepatoprotective effects on D-galactosamine-induced cytotoxicity in primary cultured mouse hepatocytes and their activities were stronger than those of related flavonoids and commercial silybin. (C) 2003 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：1045 / 1049
页数：5
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