Synthesis and Pharmacological Evaluation of Some Novel Imidazo[2,1-b][1,3,4]thiadiazole Derivatives

Synthesis of bis-1,3-{6'-arylimidazo[2,1-b][1,3,4]thiadiazol-2-yl}-1,2,2-trimethylcyclopentane (3), bis-1,3-{thiadiazolo[2',3':2,1]imidazo[4,5-b]quinoxalinyl}-1,2,2-trimethylcyclopentane (5) has been achieved by the reaction of bis-(5'-amino-1',3',4'-thiadiazolyl)-1,2,2-trimethylcyclopentane with alpha-haloketones, 2,3-dichloroquinoxaline respectively. Bromination of compound 3 furnished bis-1,3-(5'-bromo-6'-arylimidazo[2,1-b][1,3,4]thiadiazol-2-yl)-1,2,2-trimethylcyclopentane (4). The structural assignment of these compounds was supported by IR, (1)H NMR and elemental analysis data. The antimicrobial, anti-inflammatory and antifungal activities of some of the compounds have also been evaluated.