Effect of C111T polymorphism in exon 9 of the catalase gene on blood catalase activity in different types of diabetes mellitus

被引：15
作者：
Tarnai, I.
Csordas, M.
Sukei, E.
Shemirani, A. H.
Kaplar, M.
Goth, L. [1 ]
机构：
[1] Univ Debrecen, Med & Hlth Sci Ctr, Dept Clin Analyt Chem, H-4032 Debrecen, Hungary
[2] Univ Debrecen, Med & Hlth Sci Ctr, Dept Clin Biochem & Mol Pathol, H-4032 Debrecen, Hungary
[3] Univ Debrecen, Med & Hlth Sci Ctr, Dept Internal Med, H-4032 Debrecen, Hungary
来源：
FREE RADICAL RESEARCH | 2007年 / 41卷 / 07期
基金：
匈牙利科学研究基金会;
关键词：
diabetes mellitus : type 1; type; 2; gestational; blood catalase; C111T polymorphism in exon 9; mutation determination;
D O I：
10.1080/10715760701381778
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Hydrogen peroxide plays a major role in the pathomechanism of diabetes mellitus and its main regulator is enzyme catalase. The blood catalase and the C111T polymorphism in exon 9 was examined in type 1, type 2 and gestational diabetes mellitus. Compared to the control group (104.7 +/- 18.5 MU/l) significantly decreased (p < 0.001) blood catalase activities were detected in type 2 (71.2 +/- 14.6 MU/l), gestational (68.5 +/- 12.2 MU/l) diabetes mellitus and without change in type 1 ( 102.5 +/- 26.9 MU/l). The blood catalase decreased (p = 0.043) with age for type 2 diabetics and did not change (p = 0.063) for type 1, gestational diabetic patients and controls. Blood catalase showed a weak association with hemoglobin Alc for type 1 diabetic patients (r = 0.181, increasing). The mutant Tallele was increased in type 1 and gestational diabetes mellitus, and CT + TT genotypes showed decreased blood catalase activity for type 1 and increased activities for type 2 diabetic patients. The C111T polymorphism may implicate a very weak effect on blood catalase activity in different types of diabetes mellitus.
引用
收藏
页码：806 / 811
页数：6
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