Indium-catalyzed C(sp3)-H functionalization of 2-methylazaarenes through direct benzylic addition to trifluoromethyl ketones

被引：21

作者：

Jamal, Zaini ^{[1
]}

Teo, Yong-Chua ^{[1
]}

机构：

[1] Nanyang Technol Univ, Natl Inst Educ, Nat Sci & Sci Educ, Singapore 637616, Singapore

来源：

RSC ADVANCES | 2015年 / 5卷 / 34期

关键词：

H BOND FUNCTIONALIZATION; ASYMMETRIC ALLYLIC ALKYLATIONS; N-SULFONYL ALDIMINES; ORGANIC-SYNTHESIS; TRANSITION-METAL; C-C; NUCLEOPHILIC-ADDITION; 2-ALKYL AZAARENES; METHYL AZAARENES; AQUEOUS-MEDIA;

D O I：

10.1039/c4ra17182a

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The application of trivalent indium for the Lewis acid-catalyzed C(sp(3))-H functionalization of 2-methylazaarenes is reported. InCl3 was discovered to catalyze the direct addition of the benzylic C-H bond in the azaarenes to trifluoromethyl ketones. An ample number of substrates were cogently demonstrated to give the products as tri-fluoromethylated alcohols whereby in some cases, up to quantitative yield (99%) could be obtained.

引用

页码：26949 / 26953

页数：5

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