The telomere story or the triumph of an open-minded research

被引：17
作者：
Gilson, Eric [1 ,2 ]
Segal-Bendirdjian, Evelyne [3 ,4 ]
机构：
[1] CHU Nice, Archet Hosp 2, Dept Med Genet, Nice, France
[2] Univ Nice Sophia Antipolis, CNRS, INSERM, Lab Biol & Pathol Genomes,Fac Med, Nice, France
[3] INSERM, UMR S 1007, F-75006 Paris, France
[4] Paris Descartes Univ, F-75006 Paris, France
来源：
BIOCHIMIE | 2010年 / 92卷 / 04期
关键词：
Telomere; Telomerase; 2009 Nobel prize in Medicine or Physiology; DIPLOID CELL STRAINS; MAMMALIAN TELOMERES; IMMORTAL CELLS; TERMINAL TRANSFERASE; HUMAN FIBROBLASTS; MARROW FAILURE; RNA; LENGTH; TETRAHYMENA; ELONGATION;
D O I：
10.1016/j.biochi.2009.12.014
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The Nobel Assembly at Karolinska Institute has decided to award The Nobel Prize in Physiology or Medicine 2009 jointly to Elizabeth H. Blackburn, Carol W. Greider and Jack W. Szostak for the discovery of "how chromosomes are protected by telomeres and the enzyme telomerase". This discovery had major impacts within the scientific community and led to intense research in this field. All the studies performed are now the bases for future investigations and stimulate the development of potential new therapies. (C) 2010 Elsevier Masson SAS. All rights reserved.
引用
收藏
页码：321 / 326
页数：6
相关论文
共 64 条
  • [1] Telomerase does not counteract telomere shortening but protects mitochondrial function under oxidative stress
    Ahmed, Shaheda
    Passos, Joao F.
    Birket, Matthew J.
    Beckmann, Tina
    Brings, Sebastian
    Peters, Heiko
    Birch-Machin, Mark A.
    von Zglinicki, Thomas
    Saretzki, Gabriele
    [J]. JOURNAL OF CELL SCIENCE, 2008, 121 (07) : 1046 - 1053
  • [2] TELOMERE LENGTH PREDICTS REPLICATIVE CAPACITY OF HUMAN FIBROBLASTS
    ALLSOPP, RC
    VAZIRI, H
    PATTERSON, C
    GOLDSTEIN, S
    YOUNGLAI, EV
    FUTCHER, AB
    GREIDER, CW
    HARLEY, CB
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (21) : 10114 - 10118
  • [3] Telomerase mutations in families with idiopathic pulmonary fibrosis
    Armanios, Mary Y.
    Chen, Julian J. -L.
    Cogan, Joy D.
    Alder, Jonathan K.
    Ingersoll, Roxann G.
    Markin, Cheryl
    Lawson, William E.
    Xie, Mingyi
    Vulto, Irma
    Phillips, John A., III
    Lansdorp, Peter M.
    Greider, Carol W.
    Loyd, James E.
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 2007, 356 (13) : 1317 - 1326
  • [4] Telomeric repeat-containing RNA and RNA surveillance factors at mammalian chromosome ends
    Azzalin, Claus M.
    Reichenbach, Patrick
    Khoriauli, Lela
    Giulotto, Elena
    Lingner, Joachim
    [J]. SCIENCE, 2007, 318 (5851) : 798 - 801
  • [5] Telomeric localization of TRF2, a novel human telobox protein
    Bilaud, T
    Brun, C
    Ancelin, K
    Koering, CE
    Laroche, T
    Gilson, E
    [J]. NATURE GENETICS, 1997, 17 (02) : 236 - 239
  • [6] The telobox, a Myb-related telomeric DNA binding motif found in proteins from yeast, plants and human
    Bilaud, T
    Koering, CE
    BinetBrasselet, E
    Ancelin, K
    Pollice, A
    Gasser, SM
    Gilson, E
    [J]. NUCLEIC ACIDS RESEARCH, 1996, 24 (07) : 1294 - 1303
  • [7] TANDEMLY REPEATED SEQUENCE AT TERMINI OF EXTRACHROMOSOMAL RIBOSOMAL-RNA GENES IN TETRAHYMENA
    BLACKBURN, EH
    GALL, JG
    [J]. JOURNAL OF MOLECULAR BIOLOGY, 1978, 120 (01) : 33 - 53
  • [8] The epigenetic regulation of mammalian telomeres
    Blasco, Maria A.
    [J]. NATURE REVIEWS GENETICS, 2007, 8 (04) : 299 - 309
  • [9] Extension of life-span by introduction of telomerase into normal human cells
    Bodnar, AG
    Ouellette, M
    Frolkis, M
    Holt, SE
    Chiu, CP
    Morin, GB
    Harley, CB
    Shay, JW
    Lichtsteiner, S
    Wright, WE
    [J]. SCIENCE, 1998, 279 (5349) : 349 - 352
  • [10] The many faces of telomerase: emerging extratelomeric effects
    Bollmann, F. Mathias
    [J]. BIOESSAYS, 2008, 30 (08) : 728 - 732
1234567