Dibutylamine (DBA): A highly efficient catalyst for the synthesis of pyrano[2,3-d]pyrimidine derivatives in aqueous media

被引：40

作者：

Bhat, Ajmal R. ^{[1
]}

Shalla, Aabid H. ^{[2
]}

Dongre, Rajendra S. ^{[1
]}

机构：

[1] RTM Nagpur Univ, Dept Chem, Nagpur 440033, Maharashtra, India

[2] Islamic Univ Sci & Technol, Jammu 192122, Jammu & Kashmir, India

来源：

JOURNAL OF TAIBAH UNIVERSITY FOR SCIENCE | 2016年 / 10卷 / 01期

关键词：

Annulated pyrano[2,3-d]pyrimidines; Barbituric acid; Knoevenagel-Michael addition reaction; Spectral analysis; Aromatic aldehydes; DBA catalyst; ONE-POT SYNTHESIS; 3-COMPONENT SYNTHESIS; INHIBITORS;

D O I：

10.1016/j.jtusci.2015.03.004

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Annulated pyrano[2,3-d]pyrimidine derivatives were synthesized via one-pot, three-component condensation reactions of various aromatic aldehydes, malononitrile and barbituric acid in aqueous ethanol using dibutylamine (DBA) as catalyst. The potential application of DBA in organic synthesis is increasing rapidly due to its reaction simplicity, minimal reaction time, high yields of the desired products (83-94%) and low cost chemicals. All of the synthesized pyrano[2,3-d]pyrimidine derivatives were characterized by IR, H-1 NMR, C-13 NMR and mass spectra. (C) 2015 The Authors. Production and hosting by Elsevier B.V. on behalf of Taibah University. This is an open access article under the CC BY-NC-ND license (http:/creativecommons.org/licenses/by-nc-nd/4.0/).

引用

页码：9 / 18

页数：10

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