Antifungal activity of nikkomycin Z against Candida auris

被引：21

作者：

Bentz, Meghan L. ^{[1
]}

Nunnally, Natalie ^{[1
]}

Lockhart, Shawn R. ^{[1
]}

Sexton, D. Joseph ^{[1
]}

Berkow, Elizabeth L. ^{[1
]}

机构：

[1] Ctr Dis Control & Prevent, Mycot Dis Branch, 1600 Clifton Rd,Mailstop H17-2, Atlanta, GA 30333 USA

来源：

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY | 2021年 / 76卷 / 06期

关键词：

COMBINATION; ALBICANS;

D O I：

10.1093/jac/dkab052

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Background: Nikkomycin Z is a competitive inhibitor of chitin synthase-an enzyme needed for synthesis of the fungal cell wall. Nikkomycin Z shows promise as a treatment for coccidioidomycoses and mixed activity has been described against other fungi and yeast. To our knowledge, it has not previously been tested against the emerging fungal pathogen Candida auris. Objectives: To determine the in vitro activity of nikkomycin Z against C. auris. Methods: Nikkomycin Z was tested by broth microdilution against a panel of 100 isolates of genetically diverse C. auris from around the world. Results: Nikkomycin Z showed mixed activity against the tested isolates, with an MIC range of 0.125 to >64 mg/L. The MIC50 and MIC90 were 2 and 32 mg/L, respectively. Conclusions: These findings suggest nikkomycin Z has in vitro activity against some, but not all isolates of C. auris.

引用

页码：1495 / 1497

页数：3

共 9 条

[1]

Centers for Disease Control and Prevention (U.S.), 2019, Antibiotic Resistance Threats in the United States

[2] CHITIN BIOSYNTHESIS IN CANDIDA-ALBICANS GROWN-INVITRO AND INVIVO AND ITS INHIBITION BY NIKKOMYCIN-Z [J].