Investigation of mitochondrial DNA copy number in patients with major depressive disorder

被引：37

作者：

Chung, Jae Kyung ^{[1
]}

Lee, Soo Young ^{[2
]}

Park, Mira ^{[3
]}

Joo, Eun-Jeong ^{[4
,5
]}

Kim, Soon Ae ^{[2
]}

机构：

[1] Eumsung Somang Hosp, Dept Psychiat, Eumsung, South Korea

[2] Eulji Univ, Sch Med, Dept Pharmacol, 77 Gyeryong Ro 771 Beon Gil, Daejeon 34824, South Korea

[3] Eulji Univ, Sch Med, Dept Prevent Med, Daejeon, South Korea

[4] Eulji Univ, Sch Med, Dept Neuropsychiat, Daejeon, South Korea

[5] Eulji Univ, Nowon Eulji Med Ctr, Dept Neuropsychiat, Dept Psychiat, 68 Hangeulbiseokro, Seoul 01830, South Korea

来源：

PSYCHIATRY RESEARCH | 2019年 / 282卷

基金：

新加坡国家研究基金会;

关键词：

Displacement loop; Major depressive disorder; Methylation; Mitochondria; Peroxisome-proliferator-activated receptor gamma co-activator-1 alpha; PERIPHERAL-BLOOD CELLS; LOOP REGION; METHYLATION; DYSFUNCTION; BIOGENESIS; PIOGLITAZONE; HIPPOCAMPUS; PGC-1-ALPHA; METABOLISM; PROMOTER;

D O I：

10.1016/j.psychres.2019.112616

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

Mitochondrial dysfunction is implicated in the pathophysiology of major depressive disorder (MDD). This dysfunction can be indirectly assessed using the mitochondrial DNA (mtDNA) copy number. A total of 118 patients with MDD and 116 age- and sex-matched control subjects were recruited for this study, and mtDNA copy numbers were measured in peripheral blood cells. This study also examined the potential variables that might impact mtDNA copy number in MDD, including age and clinical features. Additionally, epigenetic control of mtDNA copy number was examined by assessing DNA methylation ratios in the peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC1 alpha) promoter in nuclear DNA and the displacement loop (D-loop) region of mtDNA. The present results showed that patients with MDD had a higher mtDNA copy number and a decreased DNA methylation status in the PGC1a promoter. mtDNA copy numbers were negatively associated with an age, psychomotor agitation, and somatic symptoms in MDD. These results suggest that the alterations in mitochondrial function and epigenetic change of PGC1a may be relevant to the pathophysiology of MDD.

引用

页数：8

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