Regulatory iNKT cells lack expression of the transcription factor PLZF and control the homeostasis of Treg cells and macrophages in adipose tissue

被引：315

作者：

Lynch, Lydia ^{[1
]}

Michelet, Xavier ^{[1
]}

Zhang, Sai ^{[2
]}

Brennan, Patrick J. ^{[1
]}

Moseman, Ashley ^{[3
]}

Lester, Chantel ^{[1
]}

Besra, Gurdyal ^{[4
]}

Vomhof-Dekrey, Emilie E. ^{[5
]}

Tighe, Mike ^{[5
]}

Koay, Hui-Fern ^{[6
,7
]}

Godfrey, Dale I. ^{[6
,7
]}

Leadbetter, Elizabeth A. ^{[5
]}

Sant'Angelo, Derek B. ^{[2
,8
]}

von Andrian, Ulrich ^{[3
]}

Brenner, Michael B. ^{[1
]}

机构：

[1] Harvard Univ, Brigham & Womens Hosp, Sch Med, Dept Rheumatol Immunol & Allergy, Boston, MA 02115 USA

[2] Rutgers Robert Wood Johnson Med Sch, Dept Pediat, New Brunswick, NJ USA

[3] Harvard Univ, Sch Med, Dept Microbiol & Immunol, Boston, MA USA

[4] Univ Birmingham, Sch Biosci, Birmingham, W Midlands, England

[5] Trudeau Inst, Saranac Lake, NY USA

[6] Univ Melbourne, Peter Doherty Inst, Dept Microbiol & Immunol, Parkville, Vic 3052, Australia

[7] Univ Melbourne, Australian Res Council, Ctr Excellence Adv Mol Imaging, Melbourne, Vic 3010, Australia

[8] Rutgers Robert Wood Johnson Med Sch, Child Hlth Inst New Jersey, New Brunswick, NJ USA

来源：

NATURE IMMUNOLOGY | 2015年 / 16卷 / 01期

基金：

美国国家卫生研究院; 英国医学研究理事会;

关键词：

INVARIANT NKT CELLS; LIPID-ANTIGEN PRESENTATION; CUTTING EDGE; OBESITY; PROGRAM; GAMMA; ACCUMULATION; POLARIZATION; ACTIVATION; POPULATION;

D O I：

10.1038/ni.3047

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Invariant natural killer T cells (iNKT cells) are lipid-sensing innate T cells that are restricted by the antigen-presenting molecule CD1d and express the transcription factor PLZF. iNKT cells accumulate in adipose tissue, where they are anti-inflammatory, but the factors that contribute to their anti-inflammatory nature, as well as their targets in adipose tissue, are unknown. Here we found that iNKT cells in adipose tissue had a unique transcriptional program and produced interleukin 2 (IL-2) and IL-10. Unlike other iNKT cells, they lacked PLZF but expressed the transcription factor E4BP4, which controlled their IL-10 production. The adipose iNKT cells were a tissue-resident population that induced an anti-inflammatory phenotype in macrophages and, through the production of IL-2, controlled the number, proliferation and suppressor function of regulatory T cells (T-reg cells) in adipose tissue. Thus, iNKT cells in adipose tissue are unique regulators of immunological homeostasis in this tissue.

引用

页码：85 / +

页数：12

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