Challenges in the development of an efficient enzymatic process in the pharmaceutical industry

被引：46

作者：

Yazbeck, DR ^{[1
]}

Martinez, CA ^{[1
]}

Hu, SH ^{[1
]}

Tao, JH ^{[1
]}

机构：

[1] Pfizer Global R&D, Chem Res & Dev, San Diego, CA 92121 USA

来源：

TETRAHEDRON-ASYMMETRY | 2004年 / 15卷 / 18期

关键词：

D O I：

10.1016/j.tetasy.2004.07.050

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Despite the unparalleled opportunities that have emerged for biocatalysis over the last few years, there still exist challenges that will hinder the development of an efficient enzymatic process in the pharmaceutical industry. The challenges that will be described in this report include the throughput of an enzymatic process, downstream processing issues, and competition from other toolboxes. Perspectives on economic and intellectual property issues as well as the dynamics surrounding drug intermediates that fall into different stages of the overall drug development process will also be highlighted. Finally, literature examples will be used to offer solutions to those barriers faced by enzymatic processes attempting to transition into manufacturing scale. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：2757 / 2763

页数：7

共 34 条

[1] In-situ product removal to enhance the yield of biocatalytic reactions with competing equilibria:: α-glucosidase catalysed synthesis of disaccharides [J].

Ahmed, F ;

Stein, A ;

Lye, GJ .

JOURNAL OF CHEMICAL TECHNOLOGY AND BIOTECHNOLOGY, 2001, 76 (09) :971-977

[2]

AULT A, 1973, ORG SYNTH, V5, P932

[3] Optically active amines via lipase-catalyzed methoxyacetylation [J].

Balkenhohl, F ;

Ditrich, K ;

Hauer, B ;

Ladner, W .

JOURNAL FUR PRAKTISCHE CHEMIE-CHEMIKER-ZEITUNG, 1997, 339 (04) :381-384

[4]

BALKENHOHL F, Patent No. 4332738

[5] Industrial methods for the production of optically active intermediates [J].

Breuer, M ;

Ditrich, K ;

Habicher, T ;

Hauer, B ;

Kesseler, M ;

Stürmer, R ;

Zelinski, T .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2004, 43 (07) :788-824

[6] Resolution of (RS)-phenylglycinonitrile by penicillin acylase-catalyzed acylation in aqueous medium [J].

Chilov, GG ;

Moody, HM ;

Boesten, WHJ ;

Svedas, VK .

TETRAHEDRON-ASYMMETRY, 2003, 14 (17) :2613-2617

[7] The integrated enzymatic production and downstream processing of hexyl glucoside [J].

de Roode, BM ;

van Beek, J ;

van der Padt, A ;

Franssen, MCR ;

Boom, RM .

ENZYME AND MICROBIAL TECHNOLOGY, 2001, 29 (8-9) :513-520

[8] Creation of a productive, highly enantioselective nitrilase through gene site saturation mutagenesis (GSSM) [J].

DeSantis, G ;

Wong, K ;

Farwell, B ;

Chatman, K ;

Zhu, ZL ;

Tomlinson, G ;

Huang, HJ ;

Tan, XQ ;

Bibbs, L ;

Chen, P ;

Kretz, K ;

Burk, MJ .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2003, 125 (38) :11476-11477

[9]

DITRICH K, Patent No. 19534208

[10] UNPRECEDENTED ASYMMETRIC ALDOL REACTIONS WITH 3 ALDEHYDE SUBSTRATES CATALYZED BY 2-DEOXYRIBOSE-5-PHOSPHATE ALDOLASE [J].

GIJSEN, HJM ;

WONG, CH .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1994, 116 (18) :8422-8423

← 1 2 3 4 →