Synthesis of platinum complexes from N-benzyl ethylenediamine derivatives

被引：18

作者：

de Almeida, MV ^{[1
]}

Cesar, ET

Felício, ECA

Fontes, APS

Robert-Gero, M

机构：

[1] Univ Fed Juiz Fora, Dept Quim, BR-36036330 Juiz De Fora, MG, Brazil

[2] Univ Fed Juiz Fora, Colegio Aplicacao Joao XXIII, BR-36036330 Juiz De Fora, MG, Brazil

[3] Univ Fed Minas Gerais, Dept Quim, BR-31270901 Belo Horizonte, MG, Brazil

[4] CNRS, ICSN, F-91190 Gif Sur Yvette, France

来源：

JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY | 2000年 / 11卷 / 02期

关键词：

platinum(II) complexes; N-benzyIethylenediomine; anticancer agents; substitution reactions;

D O I：

10.1590/S0103-50532000000200009

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

N-benzylethylenediamine derivatives have been prepared in good yields using methodology diferent than that described in the literature. H-1 and C-13 NMR spectra were used to characterize those compounds. Nine new platinum(II) complexes, analogs of cisplatin and carboplatin, containing these ligands have been prepared and characterized. Preliminary in vitro tests against buccal human carcinoma cell lines (KB cells) shouted that the complexes are cytotoxic.

引用

页码：154 / 158

页数：5

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