Trimeric Gαβγ protein coupling to a 3D model of G protein-coupled receptors confirming a new molecular mechanism for activation

被引：0

作者：

Nederkoorn, PHJ

Davies, RH

Timms, D

Timmerman, H

机构：

[1] Free Univ Amsterdam, Fac Chem, Dept Pharmacochem, Div Med Chem,Leiden Amsterdam Ctr Drug Res, NL-1081 HV Amsterdam, Netherlands

[2] Univ Wales Coll Cardiff, Welsh Sch Pharm, Cardiff CF1 3XF, S Glam, Wales

[3] Zeneca Pharmaceut, Macclesfield SK10 4TG, Cheshire, England

来源：

RECEPTORS & CHANNELS | 1997年 / 5卷 / 02期

关键词：

G protein; G protein-coupled receptor; GTP synthesis; molecular modelling; proton pumping; signal transduction;

D O I：

暂无

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The present-day model for G protein activation and the associated theory on how a G protein-coupled receptor may activate the G protein are summarized. Experimental data are outlined which seem not to be in accordance with this present-day model. An alternative molecular mechanism for ternary complex activation is presented together with a three-dimensional model for a receptor coupled to the appropriate trimeric G protein. This 3D structure confirms our new molecular mechanism of activation.

引用

页码：91 / +

页数：8

共 32 条

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