Absence of linkage between the interleukin-6 gene (-174 G/C) polymorphism and migraine

被引：14
|
作者：
Rainero, I
Salani, G
Valfrè, W
Savi, L
Rivoiro, C
Ferrero, M
Pinessi, L
Grimaldi, LME
机构：
[1] Univ Turin, Dept Neurosci, Neurol Headache Ctr 3, I-10126 Turin, Italy
[2] Univ Milan, Dept Neurosci, Neuroimmunol Unit, I-20122 Milan, Italy
[3] AUSL 2, Dept Neurosci, Caltanissetta, Italy
来源：
NEUROSCIENCE LETTERS | 2003年 / 343卷 / 03期
关键词：
interleukin-6; migraine; aura; tension-type headache; anxiety;
D O I：
10.1016/S0304-3940(03)00304-5
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
To assess the role of interleukin-6 (IL-6) in migraine, we analyzed the - 174 G/C IL-6 gene polymorphism in 268 patients with migraine and 305 controls. No significant difference in the distribution of IL-6 genotypes (chi(2) = 0.601, P = 0.74) and allelic frequencies (chi(2) = 0.024, P = 0.876) was found. When patients were subdivided into subgroups (migraine with aura, migraine without aura and mixed headaches), IL-6 alleles were similarly distributed. Comparison of the clinical features of the disease with the - 174 G/C IL-6 genotypes showed no significant difference. In conclusion, we found no significant association between the - 174 G/C IL-6 polymorphism and the occurrence or the clinical features of migraine. (C) 2003 Elsevier Science Ireland Ltd. All rights reserved.
引用
收藏
页码：155 / 158
页数：4
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