Regulation of pro-inflammatory cytokine production by endothelial cells following irradiation

被引：0
|
作者：
Van der Meeren, A [1 ]
Lafont, H [1 ]
Mathe, D [1 ]
机构：
[1] IPSN, Dept Protect Sante Homme & Dosimetrie, Sect Autonome Radiobiol Appliquee Med, F-92265 Fontenay Aux Roses, France
来源：
JOURNAL DE CHIMIE PHYSIQUE ET DE PHYSICO-CHIMIE BIOLOGIQUE | 1998年 / 95卷 / 04期
关键词：
endothelial cells; pro-inflammatory cytokines; anti-inflammatory cytokines;
D O I：
10.1051/jcp:1998219
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Gamma irradiation leads to an increased production of interleukin-(IL)-6 and IL-8 by human endothelial cells. In order to regulate the radio-induced production of these pro-inflammatory cytokines, we used the immunoregulatory cytokines IL-4 and IL-10. These agents were added either before or after a 10 Gy-irradiation. Our results show that it is possible to decrease the radio-induced production of IL-6 and IL-8 with the use of IL-4 and IL-10. Differences in the intensity of the response have been observed according to the time of treatment. The antiinflammatory potential of both IL-4 and IL-10 was more pronounced when added after irradiation.
引用
收藏
页码：891 / 894
页数：4
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