Effect of Oxidative Stress on Cardiovascular System in Response to Gravity

被引：33

作者：

Takahashi, Ken ^{[1
]}

Okumura, Hiroki ^{[2
]}

Guo, Rui ^{[1
,3
]}

Naruse, Keiji ^{[1
]}

机构：

[1] Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Cardiovasc Physiol, Okayama 7008558, Japan

[2] Okayama Univ, Dept Med, Okayama 7008558, Japan

[3] Harbin Med Univ, Dept Cardiovasc Surg, Harbin 150001, Heilongjiang, Peoples R China

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2017年 / 18卷 / 07期

关键词：

oxidative stress; reactive oxygen species; radiation; microgravity; HINDLIMB UNWEIGHTING RATS; SPACE RADIATION; SIMULATED MICROGRAVITY; MARS EXPLORATION; SKELETAL-MUSCLE; NITRIC-OXIDE; CELLULAR SENESCENCE; DISEASE MORTALITY; REDOX REGULATION; NADPH OXIDASES;

D O I：

10.3390/ijms18071426

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Long-term habitation in space leads to physiological alterations such as bone loss, muscle atrophy, and cardiovascular deconditioning. Two predominant factors-namely space radiation and microgravity-have a crucial impact on oxidative stress in living organisms. Oxidative stress is also involved in the aging process, and plays important roles in the development of cardiovascular diseases including hypertension, left ventricular hypertrophy, and myocardial infarction. Here, we discuss the effects of space radiation, microgravity, and a combination of these two factors on oxidative stress. Future research may facilitate safer living in space by reducing the adverse effects of oxidative stress.

引用

页数：9

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