Mosquito immune defenses against Plasmodium infection

被引：151

作者：

Cirimotich, Chris M. ^{[1
]}

Dong, Yuemei ^{[1
]}

Garver, Lindsey S. ^{[1
]}

Sim, Shuzhen ^{[1
]}

Dimopoulos, George ^{[1
]}

机构：

[1] Johns Hopkins Bloomberg Sch Publ Hlth, W Harry Feinstone Dept Mol Microbiol & Immunol, Baltimore, MD 21205 USA

来源：

DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY | 2010年 / 34卷 / 04期

基金：

美国国家卫生研究院; 美国国家科学基金会;

关键词：

Malaria; Plasmodium; Mosquito; Anopheles; Innate immunity; GRAM-NEGATIVE-BACTERIA; KAPPA-B FACTOR; FIBRINOGEN-RELATED PROTEINS; MALARIA PARASITE INFECTION; MANNOSE-BINDING PROTEIN; DROSOPHILA IMD PATHWAY; NITRIC-OXIDE SYNTHASE; ANOPHELES-GAMBIAE; PEPTIDOGLYCAN RECOGNITION; SPOROGONIC DEVELOPMENT;

D O I：

10.1016/j.dci.2009.12.005

中图分类号：

S9 [水产、渔业];

学科分类号：

0908 ;

摘要：

The causative agent of malaria, Plasmodium, has to undergo complex developmental transitions and survive attacks from the mosquito's innate immune system to achieve transmission from one host to another through the vector. Here we discuss recent findings on the role of the mosquito's innate immune signaling pathways in preventing infection by the Plasmodium parasite, the identification and mechanistic description of novel anti-parasite molecules, the role that natural bacteria harbored in the mosquito midgut might play in this immune defense and the crucial parasite and vector molecules that mediate midgut infection. (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：387 / 395

页数：9

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