Interference Localized Surface Plasmon Resonance Nanosensor Tailored for the Detection of Specific Biomolecular Interactions

被引：33

作者：

Hiep, Ha Minh ^{[1
]}

Yoshikawa, Hiroyuki ^{[1
]}

Tamiya, Eiichi ^{[1
]}

机构：

[1] Osaka Univ, Grad Sch Engn, Dept Appl Phys, Suita, Osaka 5650871, Japan

来源：

ANALYTICAL CHEMISTRY | 2010年 / 82卷 / 04期

基金：

日本学术振兴会;

关键词：

FREE OPTICAL-DETECTION; ANTIBODY; 5-FLUOROURACIL; IMMUNOASSAY;

D O I：

10.1021/ac902008x

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

In this paper, we present an innovative sensing nanomaterial for an interference localized surface plasmon resonance (iLSPR) sensor. The iLSPR is based on plasmonic gold nanoparticles with photonic thin-film multilayers of porous aluminum oxide (Al2O3) and aluminum (Al) on a substrate. With a controllable transparent Al2O3 layer and a highly reflective M layer, our new nanomaterial was able to detect refractive index (RI) changes of the surrounding environment and the specific interaction of biomolecules including biotin and avidin, 5-fluorouracil (5-FU) and its antibody, anti-5-fluorouracil (anti 5-FU), when the iLSPR surfaces were biologically functionalized. Our model nanostructure will open the way to display the plasmonic properties of other noble metal nanoparticles and to develop other functionally similar nanosensors, which could then be expanded into multiarrays.

引用

页码：1221 / 1227

页数：7

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