ATG2A transfers lipids between membranes in vitro

被引：16

作者：

Otomo, Takanori ^{[1
]}

Maeda, Shintaro ^{[1
]}

机构：

[1] Scripps Res Inst, Dept Integrat Struct & Computat Biol, La Jolla, CA 92037 USA

来源：

AUTOPHAGY | 2019年 / 15卷 / 11期

关键词：

ATG2; WIPI; ATG18; lipid transfer; membrane tethering;

D O I：

10.1080/15548627.2019.1659622

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

ATG2 is a rod-shaped membrane-tethering protein suggested to mediate the endoplasmic reticulum (ER)-phagophore association and the expansion of the phagophore. We recently demonstrated that human ATG2A transfers lipids between membranes in vitro, which led us to propose a model that the phagophore expands upon the transfer of lipids from the ER by ATG2. Here, we summarize our findings and arising issues that need to be addressed to establish the mechanism of phagophore expansion.

引用

页码：2031 / 2032

页数：2

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