Acoustofluidic control of bubble size in microfluidic flow-focusing configuration

被引：34

作者：

Chong, Zhuang Zhi ^{[1
]}

Tor, Shu Beng ^{[1
]}

Loh, Ngiap Hiang ^{[1
]}

Wong, Teck Neng ^{[1
]}

Ganan-Calvo, Alfonso M. ^{[2
]}

Tan, Say Hwa ^{[1
]}

Nam-Trung Nguyen ^{[3
]}

机构：

[1] Nanyang Technol Univ, Sch Mech & Aerosp Engn, Singapore 639798, Singapore

[2] Univ Seville, Dept Ingn Aeroespacial & Mecan Fluidos, E-41092 Seville, Spain

[3] Griffith Univ, Queensland Micro & Nanotechnol Ctr, Brisbane, Qld 4111, Australia

来源：

LAB ON A CHIP | 2015年 / 15卷 / 04期

关键词：

D O I：

10.1039/c4lc01139b

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

This paper reports a method to control the bubble size generated in a microfluidic flow-focusing configuration. With an ultrasonic transducer, we induce acoustic streaming using a forward moving, oscillating gas-liquid interface. The induced streaming substantially affects the formation process of gas bubbles. The oscillating interface acts as a pump that increases the gas flow rate significantly and forms a larger bubble. This method is applicable to a wide range of gas pressure from 30 to 90 kPa and flow rate from 380 to 2700 mu L h(-1). The bubble size can be tuned repeatedly with the response time on the order of seconds. We believe that this method will enhance the capability of a microfluidic bubble generator to produce a tunable bubble size.

引用

页码：996 / 999

页数：4

共 20 条

[1] A fast microfluidic mixer based on acoustically driven sidewall-trapped microbubbles [J].

Ahmed, Daniel ;

Mao, Xiaole ;

Juluri, Bala Krishna ;

Huang, Tony Jun .

MICROFLUIDICS AND NANOFLUIDICS, 2009, 7 (05) :727-731

[2] Bubble dispenser in microfluidic devices [J].

Cubaud, T ;

Tatineni, M ;

Zhong, XL ;

Ho, CM .

PHYSICAL REVIEW E, 2005, 72 (03)

[3] Bubble Formation Dynamics in Various Flow-Focusing Microdevices [J].

Dietrich, N. ;

Poncin, S. ;

Midoux, N. ;

Li, Huai Z. .

LANGMUIR, 2008, 24 (24) :13904-13911

[4] Rapid prototyping of microfluidic systems in poly(dimethylsiloxane) [J].

Duffy, DC ;

McDonald, JC ;

Schueller, OJA ;

Whitesides, GM .

ANALYTICAL CHEMISTRY, 1998, 70 (23) :4974-4984

[5] Ultrasound microbubble contrast agents: Fundamentals and application to gene and drug delivery [J].

Ferrara, Katherine ;

Pollard, Rachel ;

Borden, Mark .

ANNUAL REVIEW OF BIOMEDICAL ENGINEERING, 2007, 9 :415-447

[6] Scaling the formation of slug bubbles in microfluidic flow-focusing devices [J].

Fu, Taotao ;

Funfschilling, Denis ;

Ma, Youguang ;

Li, Huai Z. .

MICROFLUIDICS AND NANOFLUIDICS, 2010, 8 (04) :467-475

[7] Theoretical investigation of a technique to produce microbubbles by a microfluidic T junction [J].

Herrada, M. A. ;

Ganan-Calvo, A. M. ;

Montanero, J. M. .

PHYSICAL REVIEW E, 2013, 88 (03)

[8] Swirl flow focusing: A novel procedure for the massive production of monodisperse microbubbles [J].

Herrada, Miguel A. ;

Ganan-Calvo, Alfonso M. .

PHYSICS OF FLUIDS, 2009, 21 (04)

[9] Micro-droplet formation utilizing microfluidic flow focusing and controllable moving-wall chopping techniques [J].

Hsiung, Suz-Kai ;

Chen, Cheng-Tso ;

Lee, Gwo-Bin .

JOURNAL OF MICROMECHANICS AND MICROENGINEERING, 2006, 16 (11) :2403-2410

[10] Sonoporation of suspension cells with a single cavitation bubble in a microfluidic confinement [J].

Le Gac, Severine ;

Zwaan, Ed ;

van den Berg, Albert ;

Ohl, Claus-Dieter .

LAB ON A CHIP, 2007, 7 (12) :1666-1672

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