Periodontitis: from microbial immune subversion to systemic inflammation

被引：1997

作者：

Hajishengallis, George ^{[1
]}

机构：

[1] Univ Penn, Dept Microbiol, Penn Dent Med, Philadelphia, PA 19104 USA

来源：

NATURE REVIEWS IMMUNOLOGY | 2015年 / 15卷 / 01期

基金：

美国国家卫生研究院;

关键词：

OBSTRUCTIVE PULMONARY-DISEASE; RESPIRATORY EPITHELIAL-CELLS; AERUGINOSA-INDUCED APOPTOSIS; PORPHYROMONAS-GINGIVALIS; RHEUMATOID-ARTHRITIS; TREPONEMA-DENTICOLA; ORAL BACTERIA; DENTAL PLAQUE; IN-VIVO; SUBGINGIVAL MICROBIOTA;

D O I：

10.1038/nri3785

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Periodontitis is a dysbiotic inflammatory disease with an adverse impact on systemic health. Recent studies have provided insights into the emergence and persistence of dysbiotic oral microbial communities that can mediate inflammatory pathology at local as well as distant sites. This Review discusses the mechanisms of microbial immune subversion that tip the balance from homeostasis to disease in oral or extra-oral sites.

引用

页码：30 / 44

页数：15

共 171 条

[1] The subgingival microbiome in health and periodontitis and its relationship with community biomass and inflammation [J].

Abusleme, Loreto ;

Dupuy, Amanda K. ;

Dutzan, Nicolas ;

Silva, Nora ;

Burleson, Joseph A. ;

Strausbaugh, Linda D. ;

Gamonal, Jorge ;

Diaz, Patricia I. .

ISME JOURNAL, 2013, 7 (05) :1016-1025

[2] Sequencing ancient calcified dental plaque shows changes in oral microbiota with dietary shifts of the Neolithic and Industrial revolutions [J].

Adler, Christina J. ;

Dobney, Keith ;

Weyrich, Laura S. ;

Kaidonis, John ;

Walker, Alan W. ;

Haak, Wolfgang ;

Bradshaw, Corey J. A. ;

Townsend, Grant ;

Soltysiak, Arkadiusz ;

Alt, Kurt W. ;

Parkhill, Julian ;

Cooper, Alan .

NATURE GENETICS, 2013, 45 (04) :450-455

[3] Periodontal disease, Porphyromonas gingivalis serum antibody levels and orodigestive cancer mortality [J].

Ahn, Jiyoung ;

Segers, Stephanie ;

Hayes, Richard B. .

CARCINOGENESIS, 2012, 33 (05) :1055-1058

[4] Hemin-dependent modulation of the lipid a structure of Porphyromonas gingivalis lipopolysaccharide [J].

Al-Qutub, Montaser N. ;

Braham, Pamela H. ;

Karimi-Naser, Lisa M. ;

Liu, Xinyan ;

Genco, Caroline A. ;

Darveau, Richard P. .

INFECTION AND IMMUNITY, 2006, 74 (08) :4474-4485

[5]

Amano A, 2014, Adv Dent Res, V26, P15, DOI 10.1177/0022034514526237

[6] Oral pathobiont induces systemic inflammation and metabolic changes associated with alteration of gut microbiota [J].

Arimatsu, Kei ;

Yamada, Hitomi ;

Miyazawa, Haruna ;

Minagawa, Takayoshi ;

Nakajima, Mayuka ;

Ryder, Mark I. ;

Gotoh, Kazuyoshi ;

Motooka, Daisuke ;

Nakamura, Shota ;

Iida, Tetsuya ;

Yamazaki, Kazuhisa .

SCIENTIFIC REPORTS, 2014, 4

[7] Looking in the Porphyromonas gingivalis cabinet of curiosities: the microbium, the host and cancer association [J].

Atanasova, K. R. ;

Yilmaz, Oe .

MOLECULAR ORAL MICROBIOLOGY, 2014, 29 (02) :55-66

[8] Oral health and mortality risk from pneumonia in the elderly [J].

Awano, S. ;

Ansai, T. ;

Takata, Y. ;

Soh, I. ;

Akifusa, S. ;

Hamasaki, T. ;

Yoshida, A. ;

Sonoki, K. ;

Fujisawa, K. ;

Takehara, T. .

JOURNAL OF DENTAL RESEARCH, 2008, 87 (04) :334-339

[9] Tobacco Smoke Augments Porphyromonas gingivalis - Streptococcus gordonii Biofilm Formation [J].

Bagaitkar, Juhi ;

Daep, Carlo A. ;

Patel, Carol K. ;

Renaud, Diane E. ;

Demuth, Donald R. ;

Scott, David A. .

PLOS ONE, 2011, 6 (11)

[10] The prevalence and incidence of coronary heart disease is significantly increased in periodontitis: A meta-analysis [J].

Bahekar, Amol Ashok ;

Singh, Sarabjeet ;

Saha, Sandeep ;

Molnar, Janos ;

Arora, Rohit .

AMERICAN HEART JOURNAL, 2007, 154 (05) :830-837

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