α-β Chimeric oligo-DNA bearing intercalator-conjugated nucleobase inside the linker sequence remarkably improves thermal stability of an alternate-stranded triple helix

被引：7

作者：

Azam, ATMZ ^{[1
]}

Hasegawa, M ^{[1
]}

Moriguchi, T ^{[1
]}

Shinozuka, K ^{[1
]}

机构：

[1] Gunma Univ, Fac Engn, Dept Chem, Kiryu, Gumma 3768515, Japan

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2004年 / 14卷 / 23期

关键词：

alternate-stranded triplex; chimeric DNA; intercalator;

D O I：

10.1016/j.bmcl.2004.09.055

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Novel alpha-beta chimeric oligodeoxynucleotides bearing an intercalator-conjugated nucleobase located at the internal 4-nt linker region were synthesized, and their triplex-stabilizing property was examined. The triple helical DNA formed between the modified chimera DNA and double-stranded DNA exhibited remarkable thermal stability; however, the position of the intercalator-conjugated nucleobase had little influence on the stability. Among the examined, modified chimera DNA bearing the two intercalator-conjugated nucleobases at adjacent positions exhibited the highest stability. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：5747 / 5750

页数：4

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