Design of the Subpopulations and Intermediate Outcomes in COPD Study (SPIROMICS)

被引：311

作者：

Couper, David ^{[1
]}

LaVange, Lisa M. ^{[1
]}

Han, MeiLan ^{[2
]}

Barr, R. Graham ^{[3
]}

Bleecker, Eugene ^{[4
]}

Hoffman, Eric A. ^{[5
]}

Kanner, Richard ^{[6
]}

Kleerup, Eric ^{[7
]}

Martinez, Fernando J. ^{[8
]}

Woodruff, Prescott G. ^{[9
]}

Rennard, Stephen ^{[10
]}

机构：

[1] Univ N Carolina, Dept Biostat, Chapel Hill, NC 27514 USA

[2] Univ Michigan, Div Pulm & Crit Care, Ann Arbor, MI 48109 USA

[3] Columbia Univ, Dept Med, New York, NY USA

[4] Wake Forest Univ, Ctr Genom & Personalized Med Res, Winston Salem, NC 27109 USA

[5] Univ Iowa, Dept Radiol, Iowa City, IA 52242 USA

[6] Univ Utah, Dept Internal Med Pulm & Crit Care Med, Salt Lake City, UT USA

[7] Univ Calif Los Angeles, Dept Med, Los Angeles, CA 90024 USA

[8] Univ Michigan, Dept Internal Med, Ann Arbor, MI 48109 USA

[9] Univ Calif San Francisco, Dept Med, Div Pulm Crit Care Sleep & Allergy, San Francisco, CA USA

[10] Univ Nebraska, Dept Internal Med, Div Pulm Crit Care Sleep & Allergy, Omaha, NE 68182 USA

来源：

THORAX | 2014年 / 69卷 / 05期

关键词：

D O I：

10.1136/thoraxjnl-2013-203897

中图分类号：

R56 [呼吸系及胸部疾病];

学科分类号：

摘要：

Subpopulations and Intermediate Outcomes in COPD Study (SPIROMICS) is a multicentre observational study of chronic obstructive pulmonary disease (COPD) designed to guide future development of therapies for COPD by providing robust criteria for subclassifying COPD participants into groups most likely to benefit from a given therapy during a clinical trial, and identifying biomarkers/phenotypes that can be used as intermediate outcomes to reliably predict clinical benefit during therapeutic trials. The goal is to enrol 3200 participants in four strata. Participants undergo a baseline visit and three annual follow-up examinations, with quarterly telephone calls. Adjudication of exacerbations and mortality will be undertaken.

引用

页码：491 / 494

页数：4

共 4 条

[1]

Minino Arialdi M, 2010, Natl Vital Stat Rep, V59, P1

[2] Genetic Epidemiology of COPD (COPDGene) Study Design [J].

Regan, Elizabeth A. ;

Hokanson, John E. ;

Murphy, James R. ;

Make, Barry ;

Lynch, David A. ;

Beaty, Terri H. ;

Curran-Everett, Douglas ;

Silverman, Edwin K. ;

Crapo, James D. .

COPD-JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE, 2010, 7 (01) :32-38

[3] Evaluation of COPD longitudinally to identify predictive surrogate end-points (ECLIPSE) [J].

Vestbo, J. ;

Anderson, W. ;

Coxson, H. O. ;

Crim, C. ;

Dawber, F. ;

Edwards, L. ;

Hagan, G. ;

Knobil, K. ;

Lomas, D. A. ;

MacNee, W. ;

Silverman, E. K. ;

Tal-Singer, R. .

EUROPEAN RESPIRATORY JOURNAL, 2008, 31 (04) :869-873

[4] Chronic Obstructive Pulmonary Disease Biomarker(s) for Disease Activity Needed-Urgently [J].

Vestbo, Jorgen ;

Rennard, Stephen .

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2010, 182 (07) :863-864

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