Epigenetic regulation of persistent pain

被引：53
作者：
Bai, Guang [1 ]
Ren, Ke [1 ]
Dubner, Ronald [1 ]
机构：
[1] Univ Maryland, Sch Dent, Program Neurosci, Dept Neural & Pain Sci, Baltimore, MD 21201 USA
来源：
TRANSLATIONAL RESEARCH | 2015年 / 165卷 / 01期
基金：
美国国家卫生研究院;
关键词：
PERIPHERAL-NERVE INJURY; CHRONIC CONSTRICTION INJURY; HISTONE DEACETYLASE INHIBITORS; CPG-BINDING PROTEIN-2; EXPERIMENTALLY-INDUCED ENDOMETRIOSIS; ALLEVIATES NEUROPATHIC PAIN; SYNTHETASE GENE CONTRIBUTES; IRRITABLE-BOWEL-SYNDROME; DNA METHYLATION ANALYSIS; PRIMARY SENSORY NEURONS;
D O I：
10.1016/j.trsl.2014.05.012
中图分类号：
R446 [实验室诊断]; R-33 [实验医学、医学实验];
学科分类号：
1001 ;
摘要：
Persistent or chronic pain is tightly associated with various environmental changes and linked to abnormal gene expression within cells processing nociceptive signaling. Epigenetic regulation governs gene expression in response to environmental cues. Recent animal model and clinical studies indicate that epigenetic regulation plays an important role in the development or maintenance of persistent pain and possibly the transition of acute pain to chronic pain, thus shedding light in a direction for development of new therapeutics for persistent pain.
引用
收藏
页码：177 / 199
页数：23
相关论文
共 243 条
  • [31] Contribution of natural products to the discovery of the transient receptor potential (TRP) channels family and their functions
    Calixto, JB
    Kassuya, CAL
    André, E
    Ferreira, J
    [J]. PHARMACOLOGY & THERAPEUTICS, 2005, 106 (02) : 179 - 208
  • [32] Mechanisms of neuropathic pain
    Campbell, James N.
    Meyer, Richard A.
    [J]. NEURON, 2006, 52 (01) : 77 - 92
  • [33] MeCP2, a key contributor to neurological disease, activates and represses transcription
    Chahrour, Maria
    Jung, Sung Yun
    Shaw, Chad
    Zhou, Xiaobo
    Wong, Stephen T. C.
    Qin, Jun
    Zoghbi, Huda Y.
    [J]. SCIENCE, 2008, 320 (5880) : 1224 - 1229
  • [34] Chemg C-H, 2014, J FORMOS MED ASS
  • [35] Intrathecal miR-96 Inhibits Nav1.3 Expression and Alleviates Neuropathic Pain in Rat Following Chronic Construction Injury
    Chen, Hong-Ping
    Zhou, Wei
    Kang, Lu-Mei
    Yan, Han
    Zhang, Lei
    Xu, Bao-Hua
    Cai, Wei-Hua
    [J]. NEUROCHEMICAL RESEARCH, 2014, 39 (01) : 76 - 83
  • [36] Metabotropic glutamate receptors and the control of chronic pain
    Chiechio, Santina
    Nicoletti, Ferdinando
    [J]. CURRENT OPINION IN PHARMACOLOGY, 2012, 12 (01) : 28 - 34
  • [37] The homeodomain transcription factor NK-4 acts as either a transcriptional activator or repressor and interacts with the p300 coactivator and the Groucho corepressor
    Choi, CY
    Lee, YM
    Kim, YH
    Park, T
    Jeon, BH
    Schulz, RA
    Kim, Y
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (44) : 31543 - 31552
  • [38] Hyperalgesia in Heroin Dependent Patients and the Effects of Opioid Substitution Therapy
    Compton, Peggy
    Canamar, Catherine P.
    Hillhouse, Maureen
    Ling, Walter
    [J]. JOURNAL OF PAIN, 2012, 13 (04) : 401 - 409
  • [39] Plasticity in the human central nervous system
    Cooke, S. F.
    Bliss, T. V. P.
    [J]. BRAIN, 2006, 129 : 1659 - 1673
  • [40] Antidepressant Actions of Histone Deacetylase Inhibitors
    Covington, Herbert E., III
    Maze, Ian
    LaPlant, Quincey C.
    Vialou, Vincent F.
    Ohnishi, Yoshinori N.
    Berton, Olivier
    Fass, Dan M.
    Renthal, William
    Rush, Augustus J., III
    Wu, Emma Y.
    Ghose, Subroto
    Krishnan, Vaishnav
    Russo, Scott J.
    Tamminga, Carol
    Haggarty, Stephen J.
    Nestler, Eric J.
    [J]. JOURNAL OF NEUROSCIENCE, 2009, 29 (37) : 11451 - 11460
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