Epigenetic regulation of persistent pain

被引：53
作者：
Bai, Guang [1 ]
Ren, Ke [1 ]
Dubner, Ronald [1 ]
机构：
[1] Univ Maryland, Sch Dent, Program Neurosci, Dept Neural & Pain Sci, Baltimore, MD 21201 USA
来源：
TRANSLATIONAL RESEARCH | 2015年 / 165卷 / 01期
基金：
美国国家卫生研究院;
关键词：
PERIPHERAL-NERVE INJURY; CHRONIC CONSTRICTION INJURY; HISTONE DEACETYLASE INHIBITORS; CPG-BINDING PROTEIN-2; EXPERIMENTALLY-INDUCED ENDOMETRIOSIS; ALLEVIATES NEUROPATHIC PAIN; SYNTHETASE GENE CONTRIBUTES; IRRITABLE-BOWEL-SYNDROME; DNA METHYLATION ANALYSIS; PRIMARY SENSORY NEURONS;
D O I：
10.1016/j.trsl.2014.05.012
中图分类号：
R446 [实验室诊断]; R-33 [实验医学、医学实验];
学科分类号：
1001 ;
摘要：
Persistent or chronic pain is tightly associated with various environmental changes and linked to abnormal gene expression within cells processing nociceptive signaling. Epigenetic regulation governs gene expression in response to environmental cues. Recent animal model and clinical studies indicate that epigenetic regulation plays an important role in the development or maintenance of persistent pain and possibly the transition of acute pain to chronic pain, thus shedding light in a direction for development of new therapeutics for persistent pain.
引用
收藏
页码：177 / 199
页数：23
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