A practical synthesis of 2,2-difluoro-3-amino-propanoic acid (α,α-difluoro-β-alanine)

被引：14

作者：

Cheguillaume, A ^{[1
]}

Lacroix, S ^{[1
]}

Marchand-Brynaert, J ^{[1
]}

机构：

[1] Univ Catholique Louvain, Unite Chim Organ & Med, B-1348 Louvain, Belgium

来源：

TETRAHEDRON LETTERS | 2003年 / 44卷 / 11期

关键词：

difluoro-beta-alanine; benzotriazolyl-l-methylamine; Reformatsky reaction;

D O I：

10.1016/S0040-4039(03)00243-0

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Reformatsky reaction of ethyl bromodifluoroacetate with N,N-(dibenzyl)-1H-benzotriazolyl-1-methylamine gave fully protected alpha,alpha-difluoro-beta-alanine. Hydrogenolysis and hydrolysis furnished alpha,alpha-difluoro-beta-alanine. Further transformation into N-phthalimido-alpha,alpha-difluoro-beta-alanine was described. (C) 2003 Elsevier Science Ltd. All rights reserved.

引用

页码：2375 / 2377

页数：3

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