A practical synthesis of 2,2-difluoro-3-amino-propanoic acid (α,α-difluoro-β-alanine)

被引：14
作者：
Cheguillaume, A [1 ]
Lacroix, S [1 ]
Marchand-Brynaert, J [1 ]
机构：
[1] Univ Catholique Louvain, Unite Chim Organ & Med, B-1348 Louvain, Belgium
来源：
TETRAHEDRON LETTERS | 2003年 / 44卷 / 11期
关键词：
difluoro-beta-alanine; benzotriazolyl-l-methylamine; Reformatsky reaction;
D O I：
10.1016/S0040-4039(03)00243-0
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Reformatsky reaction of ethyl bromodifluoroacetate with N,N-(dibenzyl)-1H-benzotriazolyl-1-methylamine gave fully protected alpha,alpha-difluoro-beta-alanine. Hydrogenolysis and hydrolysis furnished alpha,alpha-difluoro-beta-alanine. Further transformation into N-phthalimido-alpha,alpha-difluoro-beta-alanine was described. (C) 2003 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：2375 / 2377
页数：3
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