A detailed investigation of the preparation of 2,7-diaminosuberic acid and 2,5-diaminoadipic acid derivatives using Kolbe electrolysis

被引：36

作者：

Hiebl, J

Blanka, M

Guttman, A

Kollmann, H

Leitner, K

Mayrhofer, G

Rovenszky, F

Winkler, K

机构：

[1] Topcro Pharma Res GmbH, A-4020 Linz, Austria

[2] Hafslund Nycomed Pharma AG, A-4020 Linz, Austria

[3] Nycomed Austria AG, A-4020 Linz, Austria

来源：

TETRAHEDRON | 1998年 / 54卷 / 10期

关键词：

D O I：

10.1016/S0040-4020(97)10412-4

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The yield of protected 2,7-diaminosuberic acid (DAS) prepared by Kolbe reaction of N-protected alpha-glutamic acid esters is dependent on solvent, temperature, concentration of carboxylate anion, and protecting groups. The highest yield of protected L,L-2,7-diaminosuberic acid is obtained with Boc-Glu-OMe as starting material using MeOH/pyridine/NaOMe as electrolyte. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：2059 / 2074

页数：16

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