Synthesis of granulatimide positional analogues

被引：24

作者：

Yoshida, T ^{[1
]}

Nishiyachi, M ^{[1
]}

Nakashima, N ^{[1
]}

Murase, M ^{[1
]}

Kotani, E ^{[1
]}

机构：

[1] Showa Pharmaceut Univ, Machida, Tokyo 1948543, Japan

来源：

CHEMICAL & PHARMACEUTICAL BULLETIN | 2003年 / 51卷 / 02期

关键词：

alkaloid; indole; maleimide; imidazole; Stille coupling reaction; synthesis;

D O I：

10.1248/cpb.51.209

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The Stille coupling reaction of the stannylindole 13 with the 5-iodoimidazole derivative 14 (or 27) in the presence of PdCl2(PPh3)(2) gave the corresponding indole-imidazole coupling product 15 (or 28), thereby affording a synthetic approach to 10-methylgranulatimide (7), 15-methylgranulatimide (11), and 10,15-dimethylgranulatimide (12), as well as 10-methylisogranulatimide B (5).

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收藏

页码：209 / 214

页数：6

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