Synthesis of new thiohydantoin derivatives under phase transfer catalysis

被引：5

作者：

Abou El-Regal, M. K. ^{[1
]}

Abdalha, A. A. ^{[1
]}

El-Kassaby, M. A. ^{[1
]}

Ali, A. T. ^{[1
]}

机构：

[1] Ain Shams Univ, Fac Sci, Dept Chem, Cairo, Egypt

来源：

PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS | 2007年 / 182卷 / 04期

关键词：

thiohydantoin; phase transfer catalysis; arylidene; DIBROMOHYDANTOIN; ALKYLATION;

D O I：

10.1080/10426500601062007

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

A novel synthesis of thiohydantoin derivatives is achieved using phase transfer catalysis conditions via nucleophilic displacement of organohalogen compounds by 3-phenyl-2-thiohydantoin (1) and its arylidene derivative (6), yielding new thiohydantoin derivatives (2-9), which have pronounced biological activities and wide applications.

引用

页码：845 / 851

页数：7

共 23 条

[1]

Dehmlow E.V., 1993, PHASE TRANSFER CATAL, P65

[2] PREPARATION OF PHENYL THIOHYDANTOINS FROM SOME NATURAL AMINO ACIDS [J].