MYC and NOTCH1-positive postradiation cutaneous angiosarcoma of the breast

被引：6

作者：

Sheu, Tiffany G. ^{[1
]}

Hunt, Kelly K. ^{[2
]}

Middleton, Lavinia P. ^{[3
]}

机构：

[1] Houston Methodist Hosp, Dept Pathol & Genom Med, 6565 Fannin St,M227, Houston, TX 77030 USA

[2] Univ Texas MD Anderson Canc Ctr, Dept Breast Surg Oncol, Houston, TX 77030 USA

[3] Univ Texas MD Anderson Canc Ctr, Dept Pathol, Houston, TX 77030 USA

来源：

BREAST JOURNAL | 2021年 / 27卷 / 03期

关键词：

angiosarcoma; breast carcinoma; MYC; NOTCH1;

D O I：

10.1111/tbj.14171

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Postradiation cutaneous angiosarcoma of the breast is a rare, delayed complication of adjuvant radiation treatment for breast carcinoma and is associated with a worse prognosis than the original primary cancer. Recent studies have characterized the diagnostic utility of MYC and NOTCH1 receptor expression as markers for secondary radiation-associated angiosarcomas. Herein, we report an exophytic secondary breast angiosarcoma with MYC and NOTCH1 immunoreactivity. This case illustrates the utility of these markers for the identification of radiation-associated angiosarcoma with MYC and NOTCH1 expression, potential for targeted therapy and need to identify patients for further studies of the clinicopathologic and prognostic significance.

引用

页码：264 / 267

页数：4

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