Dydrogesterone support in threatened miscarriage

Introduction: The aim of this study was to determine whether dydrogesterone helps to preserve pregnancy in women with threatened miscarriage. Methods: 146 women who presented with mild or moderate vaginal bleeding during the first trimester of pregnancy were randomised to receive oral dydrogesterone (10 mg b.i.d.) (n = 86) or no treatment (n = 60). Dydrogesterone was continued until I week after the bleeding had stopped. All women received standard supportive care. Results: The incidence of miscarriage was significantly lower in the dydrogesterone group than in the untreated group (17.5% vs. 25%; p < 0.05). There were no statistically significant differences between the groups with respect to pregnancy complications or congenital abnormalities. Conclusion: Dydrogesterone appears to have beneficial effects in women with threatened miscarriage. (C) 2009 Elsevier Ireland Ltd. All rights reserved.