Copper- and palladium-catalyzed intramolecular aryl guanidinylation: An efficient method for the synthesis of 2-aminobenzimidazoles

被引：205

作者：

Evindar, G ^{[1
]}

Batey, RA ^{[1
]}

机构：

[1] Univ Toronto, Dept Chem, Davenport Res Labs, Toronto, ON M5S 3H6, Canada

来源：

ORGANIC LETTERS | 2003年 / 5卷 / 02期

关键词：

D O I：

10.1021/ol027061h

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The formation of 2-aminobenzimidazoles via intramolecular C-N bond formation between an aryl halide and a guanidine moiety can be achieved using either copper or palladium catalysis. Inexpensive copper salts such as Cul are generally superior to the use of palladium catalysts. Regioselective cyclizations, where R-3 = H, can be achieved in high yield under Cul/1,10-phenanthroline-catalyzed conditions, whereas palladium catalysis results in the formation of regioisomeric products.

引用

页码：133 / 136

页数：4

共 38 条

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