Bioactive Streptoglutarimides A-J from the Marine-Derived Streptomyces sp. ZZ741

被引：47

作者：

Zhang, Di ^{[1
]}

Yi, Wenwen ^{[1
]}

Ge, Hengju ^{[1
]}

Zhang, Zhizhen ^{[1
]}

Wu, Bin ^{[1
]}

机构：

[1] Zhejiang Univ, Ocean Coll, Zhoushan Campus, Zhoushan 316021, Peoples R China

来源：

JOURNAL OF NATURAL PRODUCTS | 2019年 / 82卷 / 10期

基金：

中国国家自然科学基金; 国家重点研发计划;

关键词：

GLUTARIMIDE ANTIBIOTICS; CELL-MIGRATION; MIGRASTATIN; LACTIMIDOMYCIN; CYCLOHEXIMIDE; BIOSYNTHESIS; INHIBITOR; ANALOGS; 9-METHYLSTREPTIMIDONE; FERMENTATION;

D O I：

10.1021/acs.jnatprod.9b00481

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

The new streptoglutarimides A-J (1-10) and the known streptovitacin A (11) were isolated from a marine-derived actinomycete, Streptomyces sp. ZZ741. Structures of the isolated compounds were elucidated based on their HRESIMS data, extensive NMR spectroscopic analyses, ECD calculations, Mosher's method, and a single-crystal X-ray diffraction experiment. Streptoglutarimide H (8) and streptovitacin A (11) showed potent antiproliferative activity against human glioma U87MG and U251 cells with IC50 values of 1.5-3.8 mu M for 8 and 0.05-0.22 mu M for 11. All isolated compounds exhibited antimicrobial activity with MIC values of 9-11 mu g/mL against methicillin-resistant Staphylococcus aureus, 8-12 mu g/mL against Escherichia coli, and 8-20 mu g/mL against Candida albicans.

引用

页码：2800 / 2808

页数：9

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