Multiple functions of p27 in cell cycle, apoptosis, epigenetic modification and transcriptional regulation for the control of cell growth: A double-edged sword protein

被引：154

作者：

Abbastabar, Maryam ^{[4
]}

Kheyrollah, Maryam ^{[5
]}

Azizian, Khalil ^{[6
]}

Bagherlou, Nazanin ^{[7
]}

Tehrani, Sadra Samavarchi ^{[1
,3
]}

Maniati, Mahmood ^{[8
]}

Karimian, Ansar ^{[1
,2
,3
]}

机构：

[1] Babol Univ Med Sci, Hlth Res Inst, Cellular & Mol Biol Res Ctr, Babol Sar, Iran

[2] Kurdistan Univ Med Sci, Canc & Immunol Res Ctr, Sanandaj, Iran

[3] Babol Univ Med Sci, Student Res Comm, Babol Sar, Iran

[4] Univ Tehran Med Sci, Dept Clin Biochem, Fac Med, Tehran, Iran

[5] Natl Inst Genet Engn & Biotechnol, Dept Mol Med, Tehran, Iran

[6] Tabriz Univ Med Sci, Liver & Gastrointestinal Dis Res Ctr, Tabriz, Iran

[7] Univ Mohaghegh Ardabili, Dept Biol, Fac Sci, Ardebil, Iran

[8] Ahvaz Jundishapur Univ Med Sci, Ahvaz, Iran

来源：

DNA REPAIR | 2018年 / 69卷

关键词：

p27; Apoptosis; Cell cycle; Epigenetic; EPITHELIAL-MESENCHYMAL TRANSITION; HISTONE-DEACETYLASE INHIBITORS; BREAST-CANCER; TUMOR-SUPPRESSOR; GASTRIC-CANCER; MEDIATED REPRESSION; NEGATIVE REGULATORS; UBIQUITIN LIGASE; CYTOPLASMIC P27; RETINOIC ACID;

D O I：

10.1016/j.dnarep.2018.07.008

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The cell cycle is controlled by precise mechanisms to prevent malignancies such as cancer, and the cell needs these tight and advanced controls. Cyclin dependent kinase inhibitor p27 (also known as KIP1) is a factor that inhibits the progression of the cell cycle by using specific molecular mechanisms. The inhibitory effect of p27 on the cell cycle is mediated by CDKs inhibition. Other important functions of p27 include cell proliferation, cell differentiation and apoptosis. Post- translational modification of p27 by phosphorylation and ubiquitination respectively regulates interaction between p27 and cyclin/CDK complex and degradation of p27. In this review, we focus on the multiple function of p27 in cell cycle regulation, apoptosis, epigenetic modifications and post translational modification, and briefly discuss the mechanisms and factors that have important roles in p27 functions.

引用

页码：63 / 72

页数：10

共 169 条

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