Mossy cells of the dentate gyrus: Drivers or inhibitors of epileptic seizures?

被引：7

作者：

Kecskes, Angela ^{[1
]}

Czeh, Boldizsar ^{[2
]}

Kecskes, Miklos ^{[3
,4
]}

机构：

[1] Univ Pecs, Szentagotha Res Ctr, Ctr Neurosc, Dept Pharmacol & Pharmacotherapy,Mol Pharmacol Res, H-7624 Pecs, Hungary

[2] Univ Pecs, Med Sch & Szentagotha Res Ctr, Ctr Neurosc, Dept Lab Med,Histol & Light Microscopy Core Facil, H-7624 Pecs, Hungary

[3] Univ Pecs, Inst Physiol, Ctr Neurosc, Med Sch,Mol Neuroendocrinol Res Grp, H-7624 Pecs, Hungary

[4] Univ Pecs, Inst Physiol, Szentagotha Res Ctr, Ctr Neurosci,Mol Neuroendocrinol Res Grp, H-7624 Pecs, Hungary

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH | 2022年 / 1869卷 / 09期

关键词：

Epilepsy; Mossy cell; Granule cell; hippocampus; Dentate gyrus; TEMPORAL-LOBE EPILEPSY; GRANULE CELLS; LONG-TERM; PATTERN SEPARATION; GABA RELEASE; THETA RHYTHM; HILAR REGION; MOUSE MODEL; RAT; HIPPOCAMPUS;

D O I：

10.1016/j.bbamcr.2022.119279

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Mossy cells (MCs) are glutamatergic cells of the dentate gyrus with an important role in temporal lobe epilepsy. Under physiological conditions MCs can control both network excitations via direct synapses to granule cells and inhibition via connections to GABAergic interneurons innervating granule cells. In temporal lobe epilepsy mossy cell loss is one of the major hallmarks, but whether the surviving MCs drive or inhibit seizure initiation and generalization is still a debate. The aim of the present review is to summarize the latest findings on the role of mossy cells in healthy and overexcited hippocampus.

引用

页数：6

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