Mossy cells of the dentate gyrus: Drivers or inhibitors of epileptic seizures?

被引：7

作者：

Kecskes, Angela ^{[1
]}

Czeh, Boldizsar ^{[2
]}

Kecskes, Miklos ^{[3
,4
]}

机构：

[1] Univ Pecs, Szentagotha Res Ctr, Ctr Neurosc, Dept Pharmacol & Pharmacotherapy,Mol Pharmacol Res, H-7624 Pecs, Hungary

[2] Univ Pecs, Med Sch & Szentagotha Res Ctr, Ctr Neurosc, Dept Lab Med,Histol & Light Microscopy Core Facil, H-7624 Pecs, Hungary

[3] Univ Pecs, Inst Physiol, Ctr Neurosc, Med Sch,Mol Neuroendocrinol Res Grp, H-7624 Pecs, Hungary

[4] Univ Pecs, Inst Physiol, Szentagotha Res Ctr, Ctr Neurosci,Mol Neuroendocrinol Res Grp, H-7624 Pecs, Hungary

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH | 2022年 / 1869卷 / 09期

关键词：

Epilepsy; Mossy cell; Granule cell; hippocampus; Dentate gyrus; TEMPORAL-LOBE EPILEPSY; GRANULE CELLS; LONG-TERM; PATTERN SEPARATION; GABA RELEASE; THETA RHYTHM; HILAR REGION; MOUSE MODEL; RAT; HIPPOCAMPUS;

D O I：

10.1016/j.bbamcr.2022.119279

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Mossy cells (MCs) are glutamatergic cells of the dentate gyrus with an important role in temporal lobe epilepsy. Under physiological conditions MCs can control both network excitations via direct synapses to granule cells and inhibition via connections to GABAergic interneurons innervating granule cells. In temporal lobe epilepsy mossy cell loss is one of the major hallmarks, but whether the surviving MCs drive or inhibit seizure initiation and generalization is still a debate. The aim of the present review is to summarize the latest findings on the role of mossy cells in healthy and overexcited hippocampus.

引用

页数：6

共 50 条

[21] Dentate Gyrus Somatostatin Cells are Required for Contextual Discrimination During Episodic Memory Encoding
Morales, Cristian
Morici, Juan Facundo
Espinosa, Nelson
Sacson, Agostina
Lara-Vasquez, Ariel
Garcia-Perez, M. A.
Bekinschtein, Pedro
Weisstaub, Noelia, V
Fuentealba, Pablo
CEREBRAL CORTEX, 2021, 31 (02) : 1046 - 1059
[22] Mossy fiber sprouting in the dentate gyrus in a newly developed epileptic mutant, Ihara epileptic rat
Amano, S
Ikeda, M
Uemura, S
Fukuoka, J
Tsuji, A
Sasahara, M
Hayase, Y
Hazama, F
BRAIN RESEARCH, 1999, 834 (1-2) : 214 - 218
[23] THE DENTATE GYRUS AS A CONTROL POINT FOR SEIZURES IN THE HIPPOCAMPUS AND BEYOND
LOTHMAN, EW
STRINGER, JL
BERTRAM, EH
EPILEPSY RESEARCH, 1992, : 301 - 313
[24] Local and Long-Range Circuit Connections to Hilar Mossy Cells in the Dentate Gyrus
Sun, Yanjun
Grieco, Steven F.
Holmes, Todd C.
Xu, Xiangmin
ENEURO, 2017, 4 (02)
[25] Rapid deletion of mossy cells does not result in a hyperexcitable dentate gyrus: Implications for epileptogenesis
Ratzliff, ADH
Howard, AL
Santhakumar, V
Osapay, I
Soltesz, I
JOURNAL OF NEUROSCIENCE, 2004, 24 (09) : 2259 - 2269
[26] Distribution, ultrastructure, and connectivity of calretinin-immunoreactive mossy cells of the mouse dentate gyrus
BlascoIbanez, JM
Freund, TF
HIPPOCAMPUS, 1997, 7 (03) : 307 - 320
[27] HYPEREXCITABILITY IN THE DENTATE GYRUS OF THE EPILEPTIC MONGOLIAN GERBIL
BUCKMASTER, PS
SCHWARTZKROIN, PA
EPILEPSY RESEARCH, 1994, 18 (01) : 23 - 28
[28] Electrographic seizures and new recurrent excitatory circuits in the dentate gyrus of hippocampal slices from kainate-treated epileptic rats
Wuarin, JP
Dudek, FE
JOURNAL OF NEUROSCIENCE, 1996, 16 (14) : 4438 - 4448
[29] Activation of ERK by spontaneous seizures in neural progenitors of the dentate gyrus in a mouse model of epilepsy
Li, Yi
Peng, Zechun
Xiao, Bo
Houser, Carolyn R.
EXPERIMENTAL NEUROLOGY, 2010, 224 (01) : 133 - 145
[30] Nonrandom connectivity of the epileptic dentate gyrus predicts a major role for neuronal hubs in seizures
Morgan, Robert J.
Soltesz, Ivan
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2008, 105 (16) : 6179 - 6184

← 1 2 3 4 5 →