Associations with autoimmune disorders and HLA class I and II antigens in inclusion body myositis

被引：68
作者：
Badrising, UA
Schreuder, GMT
Giphart, MJ
Geleijns, K
Verschuuren, JJGM
Wintzen, AR
机构：
[1] Leiden Univ, Med Ctr, Dept Neurol, NL-2300 RC Leiden, Netherlands
[2] Leiden Univ, Med Ctr, Dept Immunohematol & Blood Transfus, NL-2300 RC Leiden, Netherlands
来源：
NEUROLOGY | 2004年 / 63卷 / 12期
关键词：
D O I：
10.1212/01.WNL.0000148588.15052.4C
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Whether autoimmune mechanisms play a role in the pathogenesis of inclusion body myositis (IBM) is unknown. Human leukocyte antigen (HLA) analysis in 52 patients, including 17 with autoimmune disorders (AIDs), showed that patients were more likely to have antigens from the autoimmune-prone HLA-B8-DR3 ancestral haplotype than healthy control subjects, irrespective of the presence of AIDs. Patients lacked the apparently protective HLA-DR53 antigen. The results provide further support for an autoimmune basis in IBM.
引用
收藏
页码：2396 / 2398
页数：3
相关论文
共 11 条
  • [1] Epidemiology of inclusion body myositis in the Netherlands:: A nationwide study
    Badrising, UA
    Maat-Schieman, M
    van Duinen, SG
    Breedveld, F
    van Doorn, P
    van Engelen, B
    van den Hoogen, F
    Hoogendijk, J
    Höweler, C
    de Jager, A
    Jennekens, F
    Koehler, P
    van der Leeuw, H
    de Visser, M
    Verschuuren, JJ
    Wintzen, AR
    [J]. NEUROLOGY, 2000, 55 (09) : 1385 - 1387
  • [2] Comparison of weakness progression in inclusion body myositis during treatment with methotrexate or placebo
    Badrising, UA
    Maat-Schieman, MLC
    Ferrari, MD
    Zwinderman, AH
    Wessels, JAM
    Breedveld, FC
    van Doorn, PA
    van Engelen, BGM
    Hoogendijk, JE
    Höweler, CJ
    de Jager, AE
    Jennekens, FGI
    Koehler, PJ
    de Visser, M
    Viddeleer, A
    Verschuuren, JJ
    Wintzen, AR
    [J]. ANNALS OF NEUROLOGY, 2002, 51 (03) : 369 - 372
  • [3] BEYENBURG S, 1993, CLIN INVESTIGATOR, V71, P351
  • [4] GARLEPP MJ, 1994, CLIN EXP IMMUNOL, V98, P40
  • [5] Koffman BM, 1998, MUSCLE NERVE, V21, P115, DOI 10.1002/(SICI)1097-4598(199801)21:1<115::AID-MUS15>3.3.CO
  • [6] 2-G
  • [7] HLA allele distribution distinguishes sporadic inclusion body myositis from hereditary inclusion body myopathies
    Koffman, BM
    Sivakumar, K
    Simonis, T
    Stroncek, D
    Dalakas, MC
    [J]. JOURNAL OF NEUROIMMUNOLOGY, 1998, 84 (02) : 139 - 142
  • [8] INCLUSION BODY MYOSITIS - OBSERVATIONS IN 40 PATIENTS
    LOTZ, BP
    ENGEL, AG
    NISHINO, H
    STEVENS, JC
    LITCHY, WJ
    [J]. BRAIN, 1989, 112 : 727 - 747
  • [9] A NEW APPROACH TO THE CLASSIFICATION OF IDIOPATHIC INFLAMMATORY MYOPATHY - MYOSITIS-SPECIFIC AUTOANTIBODIES DEFINE USEFUL HOMOGENEOUS PATIENT GROUPS
    LOVE, LA
    LEFF, RL
    FRASER, DD
    TARGOFF, IN
    DALAKAS, M
    PLOTZ, PH
    MILLER, FW
    [J]. MEDICINE, 1991, 70 (06) : 360 - 374
  • [10] HLA gene and haplotype frequencies in Dutch blood donors
    Schipper, RF
    Schreuder, GMT
    Oudshoorn, M
    [J]. TISSUE ANTIGENS, 1996, 48 (05): : 562 - 574
12