Asymmetric palladium-catalyzed nucleophilic substitution of 1-(2-naphthyl)ethyl acetate by dimethyl malonate anion

被引：28

作者：

Legros, JY ^{[1
]}

Boutros, A ^{[1
]}

Fiaud, JC ^{[1
]}

Toffano, M ^{[1
]}

机构：

[1] Univ Paris 11, CNRS, UPRESA 8075,Lab Catalyse Mol Associe, Inst Chim Mol & Mat Orsay, F-91405 Orsay, France

来源：

JOURNAL OF MOLECULAR CATALYSIS A-CHEMICAL | 2003年 / 196卷 / 1-2期

关键词：

palladium; asymmetric catalysis; benzylic nucleophilic substitution; C-C bond formation; elimination;

D O I：

10.1016/S1381-1169(02)00631-3

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

The asymmetric palladium-catalyzed nucleophilic substitution of 1-(2-naphthyl)ethyl acetate (1) by dimethyl malonate anion was realized and led to dimethyl 2-[1-(2-naphthyl)ethyl]propanedioate (2) with up to 74% ee. The analysis of the course of the reaction gave some information on the behaviour of the intermediate complexes. (C) 2002 Elsevier Science B.V. All rights reserved.

引用

页码：21 / 25

页数：5

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