Study of breast cancer incidence in patients of lymphangioleiomyomatosis

被引：10

作者：

Nunez, Olivier ^{[1
,2
]}

Roman, Antonio ^{[3
]}

Johnson, Simon R. ^{[4
,5
,6
]}

Inoue, Yoshikazu ^{[7
]}

Hirose, Masaki ^{[7
]}

Casanova, Alvaro ^{[8
]}

Ruiz de Garibay, Gorka ^{[9
]}

Herranz, Carmen ^{[9
]}

Bueno-Moreno, Gema ^{[10
,11
]}

Boni, Jacopo ^{[9
]}

Mateo, Francesca ^{[9
]}

Petit, Anna ^{[12
]}

Climent, Fina ^{[12
]}

Soler, Teresa ^{[12
]}

Vidal, August ^{[12
]}

Vicente Sanchez-Mut, Jose ^{[13
]}

Esteller, Manel ^{[13
,14
,15
]}

Ignacio Lopez, Jose ^{[16
]}

Garcia, Nadia ^{[9
]}

Guma, Anna ^{[17
]}

Ortega, Raul ^{[17
]}

Jesus Pla, Maria ^{[18
]}

Campos, Miriam ^{[19
]}

Ansotegui, Emilio ^{[20
]}

Molina-Molina, Maria ^{[21
,22
]}

Valenzuela, Claudia ^{[23
]}

Ussetti, Piedad ^{[24
]}

Laporta, Rosalia ^{[24
]}

Ancochea, Julio ^{[23
]}

Xaubet, Antoni ^{[22
,25
]}

Pollan, Marina ^{[1
,2
]}

Angel Pujana, Miguel ^{[9
]}

机构：

[1] Carlos III Inst Hlth, Natl Ctr Epidemiol, Canc & Environm Epidemiol Unit, Sinesio Delgado 6, Madrid 28029, Spain

[2] Consortium Biomed Res Epidemiol & Publ Hlth CIBER, Sinesio Delgado 6, Madrid 28029, Spain

[3] Vall dHebron Univ Hosp, Lung Transplant Unit, Dept Pulmonol, Lymphangioleiomyomatosis Clin, Barcelona 08035, Catalonia, Spain

[4] Nottingham Univ Hosp NHS Trust, Natl Ctr Lymphangioleiomyomatosis, Nottingham, Notts, England

[5] Univ Nottingham, Div Resp Med, Nottingham NG7 2UH, England

[6] Univ Nottingham, Resp Res Unit, Nottingham NG7 2UH, England

[7] Natl Hosp Org, Kinki Chuo Chest Med Ctr, Sakai, Osaka 5918555, Japan

[8] Henares Hosp, Dept Pneumol, Madrid 28882, Spain

[9] Bellvitge Inst Biomed Res IDIBELL, Catalan Inst Oncol ICO, Breast Canc & Syst Biol, ProCURE, Gran Via 199, Barcelona 08908, Catalonia, Spain

[10] Autonomous Univ Madrid UAM, Dept Biochem, Biomed Res Inst Alberto Sols, Spanish Natl Res Council CSIC UAM,Hosp La Paz In, Madrid 28029, Spain

[11] MD Anderson Int Fdn, Madrid 28033, Spain

[12] Univ Hosp Bellvitge, Dept Pathol, IDIBELL, Barcelona 08908, Catalonia, Spain

[13] IDIBELL, Canc Epigenet & Biol Program, Barcelona 08908, Catalonia, Spain

[14] Univ Barcelona, Sch Med, Dept Physiol Sci 2, Barcelona 08908, Catalonia, Spain

[15] Catalan Inst Res & Adv Studies ICREA, Barcelona 08010, Catalonia, Spain

[16] Univ Basque Country, BioCruces Res Inst, Cruces Univ Hosp, Baracaldo 48903, Spain

[17] Univ Hosp Bellvitge, IDIBELL, Dept Radiol, Barcelona 08908, Catalonia, Spain

[18] Univ Hosp Bellvitge, Breast Canc Funct Unit, Dept Gynecol, ICO,IDIBELL, Barcelona 08908, Catalonia, Spain

[19] IDIBELL, ICO, Dept Med Oncol, Breast Canc Funct Unit, Barcelona 08908, Catalonia, Spain

[20] Hosp Univ & Politecn La Fe, Lung Transplant & Cyst Fibrosis Unit, Valencia 46026, Spain

[21] Univ Hosp Bellvitge, IDIBELL, Dept Pneumol, Barcelona 08908, Catalonia, Spain

[22] Consortium Biomed Res Resp Dis CIBERES, Madrid 28029, Spain

[23] Hosp La Princesa, Inst Invest Sanitaria La Princesa, Dept Pneumol, Madrid 28006, Spain

[24] Univ Hosp Clin Puerta del Hierro, Dept Pneumol, Madrid 28222, Spain

[25] Hosp Clin Barcelona, Dept Pneumol, August Pi Suner Biomed Res Inst IDIBAPS, E-08036 Barcelona, Catalonia, Spain

来源：

BREAST CANCER RESEARCH AND TREATMENT | 2016年 / 156卷 / 01期

关键词：

Breast cancer; Incidence; Lymphangioleiomyomatosis; mTOR; TSC1; TSC2; GROWTH; TUMORS; MTOR;

D O I：

10.1007/s10549-016-3737-8

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Molecular evidence has linked the pathophysiology of lymphangioleiomyomatosis (LAM) to that of metastatic breast cancer. Following on this observation, we assessed the association between LAM and subsequent breast cancer. An epidemiological study was carried out using three LAM country cohorts, from Japan, Spain, and the United Kingdom. The number of incident breast cancer cases observed in these cohorts was compared with the number expected on the basis of the country-specific incidence rates for the period 2000-2014. Immunohistochemical studies and exome sequence analysis were performed in two and one tumors, respectively. All cohorts revealed breast cancer standardized incidence ratios (SIRs) a parts per thousand yen 2.25. The combined analysis of all cases or restricted to pre-menopausal age groups revealed significantly higher incidence of breast cancer: SIR = 2.81, 95 % confidence interval (CI) = 1.32-5.57, P = 0.009; and SIR = 4.88, 95 % CI = 2.29-9.99, P = 0.0007, respectively. Immunohistochemical analyses showed positivity for known markers of lung metastatic potential. This study suggests the existence of increased breast cancer risk among LAM patients. Prospective studies may be warranted to corroborate this result, which may be particularly relevant for pre-menopausal women with LAM.

引用

页码：195 / 201

页数：7

共 22 条

[1]

Al-Saleem T, 1998, CANCER-AM CANCER SOC, V83, P2208, DOI 10.1002/(SICI)1097-0142(19981115)83:10<2208::AID-CNCR21>3.0.CO

[2]

2-K

[3] Estrogen receptor breast cancer phenotypes in the surveillance, epidemiology, and end results database [J].

Anderson, WF ;

Chatterjee, N ;

Ershler, WB ;

Brawley, OW .

BREAST CANCER RESEARCH AND TREATMENT, 2002, 76 (01) :27-36

[4] Exonic Mutations of TSC2/TSC1 Are Common but Not Seen in All Sporadic Pulmonary Lymphangioleiomyomatosis [J].

Badri, Kameswara Rao ;

Gao, Ling ;

Hyjek, Elizabeth ;

Schuger, Noa ;

Schuger, Lucia ;

Qin, Wei ;

Chekaluk, Yvonne ;

Kwiatkowski, David J. ;

Zhe, Xiaoning .

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2013, 187 (06) :663-665

[5]

Breslow N E, 1987, IARC Sci Publ, P1

[6] USING AGE OF ONSET TO DISTINGUISH BETWEEN SUBFORMS OF BREAST-CANCER [J].

CLAUS, EB ;

RISCH, NJ ;

THOMPSON, WD .

ANNALS OF HUMAN GENETICS, 1990, 54 :169-177

[7] The neural crest lineage as a driver of disease heterogeneity in Tuberous Sclerosis Complex and Lymphangioleiomyomatosis [J].

Delaney, Sean P. ;

Julian, Lisa M. ;

Stanford, William L. .

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY, 2014, 2

[8] The Mammary Stem Cell Hierarchy [J].

Fu, Naiyang ;

Lindeman, Geoffrey J. ;

Visvader, Jane E. .

STEM CELLS IN DEVELOPMENT AND DISEASE, 2014, 107 :133-160

[9] Lymphangioleiomyomatosis - a wolf in sheep's clothing [J].

Henske, Elizabeth P. ;

McCormack, Francis X. .

JOURNAL OF CLINICAL INVESTIGATION, 2012, 122 (11) :3807-3816

[10] The translational landscape of mTOR signalling steers cancer initiation and metastasis [J].

Hsieh, Andrew C. ;

Liu, Yi ;

Edlind, Merritt P. ;

Ingolia, Nicholas T. ;

Janes, Matthew R. ;

Sher, Annie ;

Shi, Evan Y. ;

Stumpf, Craig R. ;

Christensen, Carly ;

Bonham, Michael J. ;

Wang, Shunyou ;

Ren, Pingda ;

Martin, Michael ;

Jessen, Katti ;

Feldman, Morris E. ;

Weissman, Jonathan S. ;

Shokat, Kevan M. ;

Rommel, Christian ;

Ruggero, Davide .

NATURE, 2012, 485 (7396) :55-U196

← 1 2 3 →