Dysfunction of natural killer cells in patients with transitional cell carcinoma

被引：6

作者：

Lin, Chang-Te ^{[1
]}

Yu, Min-Tsung ^{[3
]}

Li, Chin ^{[2
,3
]}

Ho, Yun-Che ^{[3
]}

Shen, Cheng-Huang ^{[1
]}

Liu, Dai-Wei ^{[4
]}

Chang, De-Ching ^{[2
]}

Wu, Shu-Fen ^{[2
,3
]}

机构：

[1] Natl Chung Cheng Univ, Dept Urol, Chia Yi Christian Hosp, Chiayi, Taiwan

[2] Natl Chung Cheng Univ, Dept Life Sci, Chiayi, Taiwan

[3] Natl Chung Cheng Univ, Inst Mol Biol, Chiayi, Taiwan

[4] Tzu Chi Univ, Dept Med, Hualien, Taiwan

来源：

CANCER LETTERS | 2010年 / 291卷 / 01期

关键词：

Natural killer cell; Transitional cell carcinoma; Transforming growth factor-beta; Interferon-gamma; Innate immunity; BLADDER-CARCINOMA; GROWTH-FACTOR; TGF-BETA; NK CYTOTOXICITY; CANCER; TUMOR; ACTIVATION; EXPRESSION; TGF-BETA-1; RECEPTORS;

D O I：

10.1016/j.canlet.2009.09.019

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Previous studies had established that transforming growth factor-beta 1 (TGF-beta 1) is highly expressed in bladder tumor, facilitating progression and spreading of the cancerous cells. Here, we report that both the number and the cytotoxic function of natural killer (NK) cells are decreased in patients with superficial transitional cell carcinoma (TCC). In consistent with previously reported findings, the plasma TGF-beta 1 concentration is also elevated in patients with superficial TCC. In vitro, the cytotoxic function of NK cells was impaired by the presence of TGF-beta 1. Hence, our data suggested elevated concentration of serum TGF-beta 1 in loss of NK cytotoxicity in superficial TCC patients, implicating altered innate immunity may correlate with the incidence of TCC. (C) 2009 Elsevier Ireland Ltd. All rights reserved.

引用

页码：39 / 45

页数：7

共 30 条

[1]

[Anonymous], 2003, WORLD CANC REPORT

[2] Tumor and viral recognition by natural killer cells receptors [J].

Arnon, Tal I. ;

Markel, Gal ;

Mandelboim, Ofer .

SEMINARS IN CANCER BIOLOGY, 2006, 16 (05) :348-358

[3] NK cell activation by dendritic cells (DCs) requires the formation of a synapse leading to IL-12 polarization in DCs [J].

Borg, C ;

Jalil, A ;

Laderach, D ;

Maruyama, K ;

Wakasugi, H ;

Charrier, S ;

Ryffel, B ;

Cambi, A ;

Figdor, C ;

Vainchenker, W ;

Galy, A ;

Caignard, A ;

Zitvogel, L .

BLOOD, 2004, 104 (10) :3267-3275

[4] Natural killer cells, viruses and cancer [J].

Cerwenka, A ;

Lanier, LL .

NATURE REVIEWS IMMUNOLOGY, 2001, 1 (01) :41-49

[5] Inhibition of NK cell activity through TGF-β1 by down-regulation of NKG2D in a murine model of head and neck cancer [J].

Dasgupta, S ;

Bhattacharya-Chatterjee, M ;

O'Malley, BW ;

Chatterjee, SK .

JOURNAL OF IMMUNOLOGY, 2005, 175 (08) :5541-5550

[6] Differential impact of TGF-β and EGF on fibroblast differentiation and invasion reciprocally promotes colon cancer cell invasion [J].

Denys, Hannelore ;

Derycke, Lara ;

Hendrix, An ;

Westbroek, Wendy ;

Gheldof, Alexander ;

Narine, Kishan ;

Pauwels, Patrick ;

Gespach, Christian ;

Bracke, Marc ;

De Wever, Olivier .

CANCER LETTERS, 2008, 266 (02) :263-274

[7] Three-color flow cytometric assay for the study of the mechanisms of cell-mediated cytotoxicity [J].

Derby, E ;

Reddy, V ;

Kopp, W ;

Nelson, E ;

Baseler, M ;

Sayers, T ;

Malyguine, A .

IMMUNOLOGY LETTERS, 2001, 78 (01) :35-39

[8] Interferons, immunity and cancer immunoediting [J].

Dunn, Gavin P. ;

Koebel, Catherine M. ;

Schreiber, Robert D. .

NATURE REVIEWS IMMUNOLOGY, 2006, 6 (11) :836-848

[9] Transforming growth factors-beta 1 and beta 2 in serum and urine from patients with bladder carcinoma [J].

Eder, IE ;

Stenzl, A ;

Hobisch, A ;

Cronauer, MV ;

Bartsch, G ;

Klocker, H .

JOURNAL OF UROLOGY, 1996, 156 (03) :953-957

[10] Increased interleukin-10 serum levels in patients with solid tumours [J].

Fortis, C ;

Foppoli, M ;

Gianotti, L ;

Galli, L ;

Citterio, G ;

Consogno, G ;

Gentilini, O ;

Braga, M .

CANCER LETTERS, 1996, 104 (01) :1-5

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