Functionalized nanoporous gold membrane for pancreatic islet cells encapsulation

被引：4
|
作者：
Chen, Shi-ting [1 ]
He, Si-yuan [1 ]
Wang, Wan-ying [2 ]
Jin, Hai-jun [3 ]
Lu, Jian [4 ]
Zhang, Ye-yuan [3 ]
机构：
[1] Southeast Univ, Sch Biol Sci & Med Engn, State Key Lab Bioelect, Jiangsu Key Lab Biomat & Devices, Nanjing 210096, Peoples R China
[2] City Univ Hong Kong, Dept Biomed Sci, Hong Kong, Peoples R China
[3] Chinese Acad Sci, Inst Met Res, Shenyang Natl Lab Mat Sci, Shenyang 110016, Peoples R China
[4] City Univ Hong Kong, Dept Mech Engn, Hong Kong, Peoples R China
来源：
MATERIALS LETTERS | 2021年 / 301卷
关键词：
Nanoporous gold; Dealloying; Cell encapsulation; Diabetes treatment; Biomaterials; Porous material;
D O I：
10.1016/j.matlet.2021.130224
中图分类号：
T [工业技术];
学科分类号：
08 ;
摘要：
Nanoporous gold (NPG) is promising to functionalize as an immunoisolation membrane in cell encapsulation therapy (CET) due to its tunable pore structure. Herein, we evaluated the potential utilization of NPG membrane for the encapsulation of pancreatic islet cells, that is, a practical CET to correct the diabetic state. The results showed that the NPG membrane maintained the viability of mouse insulinoma 6 (MIN6) cells and allowed the sufficient exchange of substances for cell metabolism over 4 days. In vitro, the glucose-stimulated insulin released by encapsulated cells was detected, demonstrating the functional performance of the NPG-encapsulation.
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页数：3
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