Hypoxia-induced autophagy contributes to the chemoresistance of hepatocellular carcinoma cells

被引：164

作者：

Song, Jianrui ^{[1
]}

Qu, Zengqiang ^{[2
]}

Guo, Xianling ^{[1
]}

Zhao, Qiudong ^{[1
]}

Zhao, Xue ^{[1
]}

Gao, Lu ^{[1
]}

Sun, Kai ^{[1
]}

Shen, Feng ^{[1
]}

Wu, Mengchao ^{[1
]}

Wei, Lixin ^{[1
]}

机构：

[1] Second Mil Med Univ, Eastern Hepatobiliary Surg Hosp, Tumor Immunol & Gene Therapy Ctr, Shanghai, Peoples R China

[2] Second Mil Med Univ, Eastern Hepatobiliary Surg Hosp, Dept Radiointervent Treatment, Shanghai, Peoples R China

来源：

AUTOPHAGY | 2009年 / 5卷 / 08期

基金：

中国国家自然科学基金;

关键词：

hepatocellular carcinoma; hypoxia; chemoresistance; apoptosis; autophagy; ISOLATED RAT HEPATOCYTES; TUMOR HYPOXIA; INDUCIBLE FACTOR; CANCER-CELLS; MAMMALIAN-CELLS; SELF-DIGESTION; BREAST-CANCER; CYCLE ARREST; PROTEIN; APOPTOSIS;

D O I：

10.4161/auto.5.8.9996

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Hypoxia commonly exists in solid tumors. Under such adverse conditions, adaptive responses including autophagy are usually provoked to promote cell survival. In our study, autophagy, a lysosomal-mediated degradation pathway, is demonstrated as a protective way to make hepatocellular carcinoma cells resistant to chemotherapy under hypoxia. Compared with normoxia, chemotherapeutic agent-induced cell death under hypoxia was significantly decreased, as a result of the reduced apoptosis. However, when autophagy was inhibited by 3-MA or siRNA targeted Beclin 1, this reduction was reversed, i.e., chemoresistance was attenuated, which means autophagy mediates the chemoresistance under hypoxia. In conclusion, autophagy decreases hepatoma cells sensitization to chemotherapeutic agents by affecting their apoptotic potential.

引用

页码：1131 / 1144

页数：14

共 66 条

[1] Autophagy delays apoptotic death in breast cancer cells following DNA damage [J].